Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 4/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | WNT3A | P56704 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 3/20 | 0.41 |
| ▸ | PPARA | Q07869 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.39 |
| ▸ | MAP3K6 | O95382 | 1/20 | 0.39 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL213604 | 0.88 | CTSK (0.57) | NOTUMCTSKALDH1A1KDM4EABL1 | |
| SCHEMBL22550481 | 0.78 | NOTUM (0.49) | NOTUMCTSKALDH1A1KDM4EABL1 | |
| SCHEMBL20718135 | 0.78 | NOTUM (0.49) | NOTUMCTSKALDH1A1KDM4EABL1 | |
| SCHEMBL22550526 | 0.78 | NOTUM (0.49) | NOTUMCTSKALDH1A1KDM4EABL1 | |
| SCHEMBL9606798 | 0.76 | NOTUM (0.47) | NOTUMCTSKALDH1A1KDM4EABL1 | |
| SCHEMBL14658243 | 0.76 | NOTUM (0.51) | NOTUMALDH1A1KDM4EABL1MTOR | |
| SCHEMBL22793399 | 0.75 | NOTUM (0.52) | NOTUMCTSKALDH1A1KDM4EABL1 | |
| SCHEMBL22550382 | 0.73 | NOTUM (0.50) | NOTUMCTSKALDH1A1KDM4EABL1 | |
| SCHEMBL20718428 | 0.73 | NOTUM (0.50) | NOTUMCTSKALDH1A1KDM4EABL1 | |
| SCHEMBL20718421 | 0.73 | NOTUM (0.50) | NOTUMCTSKALDH1A1KDM4EABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |