Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 1/20 | 0.57 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 9/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.45 |
| ▸ | PTGES | O14684 | 5/20 | 0.45 |
| ▸ | PPARA | Q07869 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KLK7 | P49862 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | WNT3A | P56704 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL215045 | 0.88 | NOTUM (0.49) | CTSKNOTUMPPARGPPARAKDM4E | |
| SCHEMBL212869 | 0.78 | CTSK (0.51) | CTSKNOTUMPPARGPPARAKDM4E | |
| SCHEMBL2837600 | 0.77 | CTSK (0.52) | CTSKNOTUMKDM4EALDH1A1ABL1 | |
| SCHEMBL14658243 | 0.72 | NOTUM (0.51) | NOTUMKDM4EALDH1A1ABL1MTOR | |
| SCHEMBL22793399 | 0.72 | NOTUM (0.52) | CTSKNOTUMKDM4EALDH1A1ABL1 | |
| SCHEMBL20718135 | 0.71 | NOTUM (0.49) | CTSKNOTUMKDM4EALDH1A1ABL1 | |
| SCHEMBL22550526 | 0.71 | NOTUM (0.49) | CTSKNOTUMKDM4EALDH1A1ABL1 | |
| SCHEMBL22550481 | 0.71 | NOTUM (0.49) | CTSKNOTUMKDM4EALDH1A1ABL1 | |
| SCHEMBL2574304 | 0.71 | EPHX1 (0.61) | CTSKNOTUMALDH1A1CHEK1 | |
| SCHEMBL22550360 | 0.71 | CTSK (0.50) | CTSKNOTUMKDM4EALDH1A1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |