Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 19/20 | 0.40 |
| ▸ | USP14 | P54578 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29968822 | 1.00 | OPRK1 (0.40) | OPRK1USP14 | |
| SCHEMBL21513232 | 0.86 | OPRK1 (0.33) | OPRK1 | |
| SCHEMBL21494392 | 0.82 | OPRK1 (0.47) | OPRK1 | |
| SCHEMBL30866880 | 0.82 | OPRK1 (0.47) | OPRK1 | |
| SCHEMBL21513238 | 0.80 | OPRK1 (0.48) | OPRK1 | |
| SCHEMBL29969591 | 0.80 | OPRK1 (0.48) | OPRK1 | |
| SCHEMBL29968881 | 0.79 | ALDH1A1 (0.44) | OPRK1USP14 | |
| SCHEMBL26131943 | 0.79 | ALDH1A1 (0.44) | OPRK1USP14 | |
| SCHEMBL26590384 | 0.78 | OPRK1 (0.41) | OPRK1USP14 | |
| SCHEMBL21513242 | 0.77 | JAK2 (0.44) | OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4327877-A2 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | XRad Therapeutics, Inc. (US) | 2024-02-28 | — | — | EP | disclosed |
| EP-4327877-A2 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | XRad Therapeutics, Inc. (US) | 2024-02-28 | — | — | EP | disclosed |
| EP-3784671-B1 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | XRAD THERAPEUTICS INC (US) | 2023-10-11 | — | — | EP | disclosed |
| EP-3784671-B1 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | XRAD THERAPEUTICS INC (US) | 2023-10-11 | — | — | EP | disclosed |
| WO-2019201283-A1 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | XRAD THERAPEUTICS, INC. (US) | 2019-10-24 | — | — | WO | disclosed |