Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.51 |
| ▸ | ERG | P11308 | 6/20 | 0.51 |
| ▸ | GPBAR1 | Q8TDU6 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21520159 | 1.00 | ALDH1A1 (0.52) | ALDH1A1CYP3A4ERGGPBAR1SMN1; SMN2 | |
| SCHEMBL7049069 | 0.90 | ALDH1A1 (0.59) | ALDH1A1CYP3A4SMN1; SMN2NPC1CYP2C9 | |
| SCHEMBL28626848 | 0.88 | ALDH1A1 (0.56) | ALDH1A1CYP3A4SMN1; SMN2NPC1CYP2C9 | |
| SCHEMBL18257057 | 0.88 | ALDH1A1 (0.56) | ALDH1A1CYP3A4SMN1; SMN2NPC1CYP2C9 | |
| SCHEMBL28630307 | 0.88 | LMNA (0.60) | ALDH1A1CYP3A4SMN1; SMN2NPC1CYP2C9 | |
| SCHEMBL3931937 | 0.87 | ALDH1A1 (0.56) | ALDH1A1CYP3A4SMN1; SMN2NPC1CYP2C9 | |
| SCHEMBL28625164 | 0.87 | ALDH1A1 (0.66) | ALDH1A1CYP3A4SMN1; SMN2NPC1CYP2C9 | |
| SCHEMBL28622865 | 0.87 | ALDH1A1 (0.55) | ALDH1A1CYP3A4SMN1; SMN2NPC1CYP2C9 | |
| SCHEMBL28923360 | 0.87 | ALDH1A1 (0.55) | ALDH1A1CYP3A4SMN1; SMN2NPC1CYP2C9 | |
| SCHEMBL11096695 | 0.86 | MEN1 (0.61) | ALDH1A1CYP3A4SMN1; SMN2NPC1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10654834-B2 | Non-systemic TGR5 agonists | Venenum Biodesign, LLC (US) | 2020-05-19 | — | — | US | disclosed |
| US-10654834-B2 | Non-systemic TGR5 agonists | Venenum Biodesign, LLC (US) | 2020-05-19 | — | — | US | disclosed |
| US-20190330191-A1 | NOVEL NON-SYSTEMIC TGR5 AGONISTS | Venenum Biodesign, LLC (US) | 2019-10-31 | — | — | US | disclosed |
| US-20190330191-A1 | NOVEL NON-SYSTEMIC TGR5 AGONISTS | Venenum Biodesign, LLC (US) | 2019-10-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190330191-A1 | NOVEL NON-SYSTEMIC TGR5 AGONISTS | GPR119, FFAR1, FFAR3 | ALDH1A1 3170/4885CYP3A4 1581/4885ERG 4431/4885 |
| US-10654834-B2 | Non-systemic TGR5 agonists | GPR119, SSTR5, FFAR3 | ALDH1A1 3118/4885CYP3A4 1537/4885ERG 4475/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.