Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP3 | P15309 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.42 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10980506 | 0.88 | PTGS1 (0.47) | PTGS1MAPTLMNACXCR1CXCR2 | |
| SCHEMBL10920070 | 0.83 | ACP3 (0.45) | ACP3AKR1C3AKR1C2PSEN1PSEN2 | |
| SCHEMBL29948859 | 0.82 | PTGS1 (0.61) | ACP3AKR1C3AKR1C2PSEN1PSEN2 | |
| SCHEMBL15695550 | 0.82 | AKR1C3 (0.49) | ACP3AKR1C3AKR1C2PSEN1PSEN2 | |
| SCHEMBL3240938 | 0.82 | PTGS1 (0.61) | ACP3AKR1C3AKR1C2PSEN1PSEN2 | |
| SCHEMBL1651840 | 0.82 | PTGS1 (0.61) | ACP3AKR1C3AKR1C2PSEN1PSEN2 | |
| SCHEMBL1492650 | 0.82 | PTGS1 (0.61) | ACP3AKR1C3AKR1C2PSEN1PSEN2 | |
| SCHEMBL20230822 | 0.82 | AKR1C3 (0.49) | ACP3AKR1C3AKR1C2PSEN1PSEN2 | |
| SCHEMBL27586341 | 0.82 | MAPT (0.48) | PTGS1MAPTLMNACXCR1CXCR2 | |
| SCHEMBL4908848 | 0.82 | MAPT (0.48) | PTGS1MAPTLMNACXCR1CXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112341362-B | Cis-para-substituted cyclohexyl amino nitrile malate, and preparation and application thereof | 永农生物科学有限公司 | 2022-08-02 | — | — | CN | claimed |
| CN-112341362-A | Cis-para-substituted cyclohexyl amino nitrile malate, and preparation and application thereof | 永农生物科学有限公司 | 2021-02-09 | — | — | CN | claimed |
| CN-111072470-A | Method for preparing 2, 5-dimethyl phenylacetyl chloride | 大连奇凯医药科技有限公司 | 2020-04-28 | — | — | CN | claimed |
| CN-109369378-B | Synthetic method of insecticide spirotetramat intermediate 2, 5-dimethyl phenylacetyl chloride | 山东省农药科学研究院 | 2020-02-18 | — | — | CN | claimed |
| CN-112341362-B | Cis-para-substituted cyclohexyl amino nitrile malate, and preparation and application thereof | 永农生物科学有限公司 | 2022-08-02 | — | — | CN | disclosed |
| CN-114409664-A | Spiro-heterocyclic tetrahydropyran compound and preparation method and application thereof | 河北威远生物化工有限公司 | 2022-04-29 | — | — | CN | disclosed |
| CN-112341362-A | Cis-para-substituted cyclohexyl amino nitrile malate, and preparation and application thereof | 永农生物科学有限公司 | 2021-02-09 | — | — | CN | disclosed |
| CN-111072470-A | Method for preparing 2, 5-dimethyl phenylacetyl chloride | 大连奇凯医药科技有限公司 | 2020-04-28 | — | — | CN | disclosed |
| CN-111072470-A | Method for preparing 2, 5-dimethyl phenylacetyl chloride | 大连奇凯医药科技有限公司 | 2020-04-28 | — | — | CN | disclosed |
| CN-111072470-A | Method for preparing 2, 5-dimethyl phenylacetyl chloride | 大连奇凯医药科技有限公司 | 2020-04-28 | — | — | CN | disclosed |
| CN-109369378-B | Synthetic method of insecticide spirotetramat intermediate 2, 5-dimethyl phenylacetyl chloride | 山东省农药科学研究院 | 2020-02-18 | — | — | CN | disclosed |
| CN-109369378-B | Synthetic method of insecticide spirotetramat intermediate 2, 5-dimethyl phenylacetyl chloride | 山东省农药科学研究院 | 2020-02-18 | — | — | CN | disclosed |
| CN-109928868-A | The synthetic method and its application of bis- (2,5- 3,5-dimethylphenyl) the propyl- 2- ketone of 1,3- | 河北科技大学 | 2019-06-25 | — | — | CN | disclosed |
| US-9365584-B2 | Thieno [2,3-B] pyridinedione activators of AMPK and therapeutic uses thereof | POXEL (FR) | 2016-06-14 | — | — | US | disclosed |
| EP-2519527-B1 | THIENO[2,3-B]PYRIDINEDIONE ACTIVATORS OF AMPK AND THERAPEUTIC USES THEREOF | POXEL (FR) | 2013-12-18 | — | — | EP | disclosed |
| WO-2013152272-A1 | ΑΖΑ-β-LACTAM COMPOUNDS AND METHODS OF USING | THE SCRIPPS RESEARCH INSTITUTE (US) | 2013-10-10 | — | — | WO | disclosed |
| US-20130053401-A1 | THIENO [2,3-B] PYRIDINEDIONE ACTIVATORS OF AMPK AND THERAPEUTIC USES THEREOF | POXEL (FR) | 2013-02-28 | — | — | US | disclosed |
| EP-2519527-A1 | THIENO [2,3-B]PYRIDINEDIONE ACTIVATORS OF AMPK AND THERAPEUTIC USES THEREOF | Poxel (FR) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080277-A1 | THIENO [2,3-B] PYRIDINEDIONE ACTIVATORS OF AMPK AND THERAPEUTIC USES THEREOF | POXEL (FR) | 2011-07-07 | — | — | WO | disclosed |
| WO-2010018435-A1 | AMIDE GLYCOSIDES | HETERO RESEARCH FOUNDATION (IN) | 2010-02-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130053401-A1 | THIENO [2,3-B] PYRIDINEDIONE ACTIVATORS OF AMPK AND THERAPEUTIC USES THEREOF | PRKAB1, PRKAG1, PRKAB2 | ACP3 669/4885AKR1C3 547/4885AKR1C2 518/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.