Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.74 |
| ▸ | HTT | P42858 | 2/20 | 0.74 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12069269 | 0.90 | ALOX5 (0.82) | ALOX5ALDH1A1HTTPOLBSMN1; SMN2 | |
| SCHEMBL3902985 | 0.86 | ALOX5 (0.75) | ALOX5ALDH1A1HTTPOLBKMT2A | |
| SCHEMBL30865951 | 0.84 | ALOX5 (0.72) | ALOX5ALDH1A1POLBKMT2A | |
| SCHEMBL12069952 | 0.83 | KMT2A (0.84) | ALOX5ALDH1A1POLBKMT2AMAPT | |
| SCHEMBL19226332 | 0.83 | ALOX5 (0.71) | ALOX5ALDH1A1HTTPOLBSMN1; SMN2 | |
| SCHEMBL12488830 | 0.83 | ALOX5 (0.71) | ALOX5ALDH1A1POLBKMT2A | |
| SCHEMBL13836513 | 0.83 | ALOX5 (0.72) | ALOX5ALDH1A1POLBKMT2A | |
| SCHEMBL11399076 | 0.82 | ALOX5 (0.69) | ALOX5ALDH1A1HTTPOLBSMN1; SMN2 | |
| SCHEMBL13836598 | 0.80 | ALOX5 (0.67) | ALOX5ALDH1A1HTTPOLBSMN1; SMN2 | |
| SCHEMBL14859480 | 0.79 | ALDH1A1 (0.73) | ALOX5ALDH1A1HTTPOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10350217-B2 | Antifungal agents and uses thereof | UNIVERSITY OF MASSACHUSETTS (US) | 2019-07-16 | — | — | US | disclosed |
| US-20170224703-A1 | ANTIFUNGAL AGENTS AND USES THEREOF | UNIVERSITY OF MASSACHUSETTS | 2017-08-10 | — | — | US | disclosed |
| US-20170224703-A1 | ANTIFUNGAL AGENTS AND USES THEREOF | UNIVERSITY OF MASSACHUSETTS | 2017-08-10 | — | — | US | disclosed |
| US-9648880-B2 | Antifungal agents and uses thereof | UNIVERSITY OF MASSACHUSETTS (US) | 2017-05-16 | — | — | US | disclosed |
| US-9648880-B2 | Antifungal agents and uses thereof | UNIVERSITY OF MASSACHUSETTS (US) | 2017-05-16 | — | — | US | disclosed |
| US-20140142107-A1 | ANTIFUNGAL AGENTS AND USES THEREOF | UNIVERSITY OF MASSACHUSETTS (US) | 2014-05-22 | — | — | US | disclosed |
| US-20140142107-A1 | ANTIFUNGAL AGENTS AND USES THEREOF | UNIVERSITY OF MASSACHUSETTS (US) | 2014-05-22 | — | — | US | disclosed |
| WO-2014039515-A2 | ANTIFUNGAL AGENTS AND USES THEREOF | UNIVERSITY OF MASSACHUSETTS (US) | 2014-03-13 | — | — | WO | disclosed |
| US-20120295890-A1 | GLYCOSAMINOGLYCAN INHIBITORS | Zacharon Pharmaceutical, Inc. (US) | 2012-11-22 | — | — | US | disclosed |
| WO-2011082175-A2 | GLYCOSAMINOGLYCAN INHIBITORS | ZACHARON PHARMACEUTICALS, INC. (US) | 2011-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140142107-A1 | ANTIFUNGAL AGENTS AND USES THEREOF | DPM1, ERG28, SUCLG1 | ALOX5 1862/4885ALDH1A1 1365/4885HTT 3624/4885 |
| US-20120295890-A1 | GLYCOSAMINOGLYCAN INHIBITORS | CSGALNACT1, FUT5, ST3GAL3 | ALOX5 3758/4885ALDH1A1 797/4885HTT 2106/4885 |
| US-20170224703-A1 | ANTIFUNGAL AGENTS AND USES THEREOF | DPM1, ERG28, SUCLG1 | ALOX5 1862/4885ALDH1A1 1365/4885HTT 3624/4885 |
| US-10350217-B2 | Antifungal agents and uses thereof | DPM1, ERG28, SUCLG1 | ALOX5 1862/4885ALDH1A1 1365/4885HTT 3624/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.