Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTR5A | P47898 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8780449 | 0.83 | BCHE (0.38) | ALDH1A1MAPK1HPGDBCHEACHE | |
| SCHEMBL11416663 | 0.82 | MEN1 (0.36) | MEN1POLBKMT2AALDH1A1HPGD | |
| SCHEMBL11412655 | 0.81 | METAP1 (0.40) | — | |
| SCHEMBL4213119 | 0.79 | MAOB (0.39) | MEN1POLBKMT2AALDH1A1 | |
| SCHEMBL8559782 | 0.79 | TDO2 (0.38) | MEN1POLBKMT2AALDH1A1TSHR | |
| SCHEMBL463373 | 0.78 | APEX1 (0.39) | MEN1POLBKMT2AALDH1A1TSHR | |
| SCHEMBL6474398 | 0.76 | CYP19A1 (0.44) | TSHRALOX15CYP1A2LMNA | |
| SCHEMBL11411069 | 0.76 | POLB (0.40) | MEN1POLBKMT2AALDH1A1ACHE | |
| SCHEMBL9482199 | 0.75 | PTPRC (0.35) | MEN1POLBKMT2AALDH1A1TSHR | |
| SCHEMBL11415071 | 0.75 | TUBB4A (0.42) | MEN1KMT2ATSHRHPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3403651-B1 | ISOCORYDINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF | LANZHOU INST CHEMICAL PHYSICS CAS (CN) | 2019-10-30 | — | — | EP | disclosed |