Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GRK2 | P25098 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL422450 | 0.82 | L3MBTL1 (0.44) | LMNASMN1; SMN2NPC1ALDH1A1RAB9A | |
| SCHEMBL3413889 | 0.80 | KDM1A (0.39) | ALDH1A1POLB | |
| SCHEMBL29473306 | 0.80 | AAK1 (0.39) | ALDH1A1HPGDL3MBTL1MAPTMEN1 | |
| SCHEMBL16110940 | 0.80 | ALDH1A1 (0.41) | LMNASMN1; SMN2ALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL18827200 | 0.78 | TRPM5 (0.50) | LMNASMN1; SMN2NPC1ALDH1A1RAB9A | |
| SCHEMBL18235935 | 0.78 | KDM4E (0.43) | LMNAMAPTMEN1KMT2AGAA | |
| SCHEMBL27169591 | 0.77 | LMNA (0.39) | LMNASMN1; SMN2NPC1ALDH1A1RAB9A | |
| SCHEMBL6931205 | 0.77 | SMN1; SMN2 (0.48) | LMNASMN1; SMN2NPC1ALDH1A1RAB9A | |
| SCHEMBL17678181 | 0.76 | LMNA (0.39) | LMNAALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL20014808 | 0.76 | LMNA (0.32) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3212642-B1 | AMIDE SUBSTITUTED THIAZOLES AS MODULATORS OF RORGAMMAT | JANSSEN PHARMACEUTICA NV (BE) | 2019-10-30 | — | — | EP | disclosed |