Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.58 |
| ▸ | CA2 | P00918 | 3/20 | 0.58 |
| ▸ | HTR6 | P50406 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20468978 | 1.00 | CA1 (0.58) | CA1CA2HTR6KDM4EMEN1 | |
| SCHEMBL8572018 | 0.98 | CA1 (0.57) | CA1CA2HTR6KDM4EMEN1 | |
| SCHEMBL15307679 | 0.78 | HTR2A (0.65) | CA1CA2HTR6KDM4EMEN1 | |
| SCHEMBL30223611 | 0.76 | HTR2A (0.67) | CA1CA2HTR6KDM4EMEN1 | |
| SCHEMBL21653604 | 0.76 | CA1 (0.57) | CA1CA2HTR6KDM4EMEN1 | |
| SCHEMBL11755532 | 0.76 | CA1 (0.62) | CA1CA2HTR6KDM4EMEN1 | |
| SCHEMBL3927394 | 0.76 | HTR2A (0.67) | CA1CA2HTR6KDM4EMEN1 | |
| SCHEMBL9059934 | 0.76 | CA1 (0.57) | CA1CA2HTR6KDM4EMEN1 | |
| SCHEMBL7427782 | 0.75 | CA1 (0.55) | CA1CA2HTR6KDM4EMEN1 | |
| SCHEMBL14155784 | 0.74 | CA1 (0.54) | CA1CA2HTR6KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10597411-B2 | Compositions and methods for inhibiting arginase activity | CALITHERA BIOSCIENCES, INC. (US) | 2020-03-24 | — | — | US | disclosed |
| US-20190330244-A1 | COMPOSITIONS AND METHODS FOR INHIBITING ARGINASE ACTIVITY | PRECISION PHARMACEUTICALS, INC. | 2019-10-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190330244-A1 | COMPOSITIONS AND METHODS FOR INHIBITING ARGINASE ACTIVITY | ARG1, ARG2, PRMT3 | CA1 850/4885CA2 702/4885HTR6 4581/4885 |
| US-10597411-B2 | Compositions and methods for inhibiting arginase activity | ARG1, ARG2, PRMT3 | CA1 850/4885CA2 702/4885HTR6 4581/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.