SCHEMBL2154207

SCHEMBL2154207

CC(C)(C)Oc1ccc(C(=O)Cl)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 6/20 0.46
PPARG P37231 4/20 0.46
FABP2 P12104 1/20 0.46
SLC22A12 Q96S37 1/20 0.46
MAPT P10636 4/20 0.44
CYP1A2 P05177 3/20 0.44
CYP3A4 P08684 3/20 0.44
MEN1 O00255 2/20 0.44
CYP2C19 P33261 2/20 0.44
KMT2A Q03164 2/20 0.44
CYP2D6 P10635 1/20 0.44
ALDH1A1 P00352 1/20 0.44
ELANE P08246 5/20 0.43
HPGD P15428 3/20 0.41
ABCB11 O95342 2/20 0.41
TSHR P16473 2/20 0.41
HTR2A P28223 2/20 0.41
PMP22 Q01453 2/20 0.41
USP2 O75604 1/20 0.41
LMNA P02545 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31019637 0.88 PPARA (0.46) PPARAPPARGFABP2SLC22A12MAPT
SCHEMBL20076975 0.83 ELANE (0.60) PPARAPPARGFABP2SLC22A12MAPT
SCHEMBL27692312 0.82 PPARA (0.42) PPARAPPARGFABP2SLC22A12MAPT
SCHEMBL3585884 0.82 PPARA (0.48) PPARAPPARGFABP2SLC22A12MAPT
SCHEMBL6520817 0.81 ALDH1A1 (0.41) PPARAPPARGFABP2SLC22A12MAPT
SCHEMBL322440 0.81 CA1 (0.59) PPARAPPARGFABP2SLC22A12KMT2A
SCHEMBL2031463 0.81 MAPT (0.61) PPARAPPARGFABP2SLC22A12MAPT
SCHEMBL25259867 0.79 ELANE (0.43) PPARAPPARGFABP2SLC22A12MAPT
SCHEMBL7769320 0.79 ELANE (0.43) PPARAPPARGFABP2SLC22A12MAPT
SCHEMBL162647 0.79 EPHX2 (0.53) RAB9ATRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119569803-A Method for preparing high-purity estetrol 秦皇岛紫竹药业有限公司 2025-03-07 CN claimed
CN-119569803-A Method for preparing high-purity estetrol 秦皇岛紫竹药业有限公司 2025-03-07 CN disclosed
WO-2022169974-A1 INHIBITORS OF URAT1 AND PHARMACEUTICAL USES THEREOF NEXYS THERAPEUTICS, INC. (US) 2022-08-11 WO disclosed
EP-3184171-B1 PHOSPHINYL AMIDINE COMPOUNDS, METAL COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OR POLYMERIZE OLEFINS CHEVRON PHILLIPS CHEMICAL CO LP (US) 2019-03-20 EP disclosed
US-10144752-B2 Phosphinyl amidine compounds, metal complexes, catalyst systems, and their use to oligomerize or polymerize olefins CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2018-12-04 US disclosed
US-20170305945-A1 Phosphinyl Amidine Compounds, Metal Complexes, Catalyst Systems, and Their Use to Oligomerize or Polymerize Olefins CHEVRON PHILLIPS CHEMICAL COMPANY LP 2017-10-26 US disclosed
US-9732106-B2 Phosphinyl amidine compounds, metal complexes, catalyst systems, and their use to oligomerize or polymerize olefins CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2017-08-15 US disclosed
EP-3184171-A1 PHOSPHINYL AMIDINE COMPOUNDS, METAL COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OR POLYMERIZE OLEFINS Chevron Phillips Chemical Company LP (US) 2017-06-28 EP disclosed
EP-2519532-B1 PHOSPHINYL AMIDINE COMPOUNDS, METAL COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OR POLYMERIZE OLEFINS CHEVRON PHILLIPS CHEMICAL CO LP (US) 2017-03-08 EP disclosed
US-20160168180-A1 Phosphinyl Amidine Compounds, Metal Complexes, Catalyst Systems, and Their Use to Oligomerize or Polymerize Olefins CHEVRON PHILLIPS CHEMICAL COMPANY LP 2016-06-16 US disclosed
WO-2011080718-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE PIRAMAL LIFE SCIENCES LIMITED (IN) 2011-07-07 WO disclosed
WO-2011082192-A1 PHOSPHINYL AMIDINE COMPOUNDS, METAL COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OR POLYMERIZE OLEFINS CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2011-07-07 WO disclosed
US-7528212-B2 Ionizing radiation stable thermoplastic composition, method of making, and articles formed therefrom SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2009-05-05 US disclosed
EP-1948712-A2 IONIZING RADIATION STABLE THERMOPLASTIC COMPOSITION, METHOD OF MAKING, AND ARTICLES FORMED THEREFROM General Electric Company (US) 2008-07-30 EP disclosed
WO-2007061672-A2 IONIZING RADIATION STABLE THERMOPLASTIC COMPOSITION, METHOD OF MAKING, AND ARTICLES FORMED THEREFROM GENERAL ELECTRIC COMPANY (US) 2007-05-31 WO disclosed
US-20070117957-A1 Ionizing radiation stable thermoplastic composition, method of making, and articles formed therefrom SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2007-05-24 US disclosed
EP-0945764-B1 Photoresist composition SUMITOMO CHEMICAL CO (JP) 2003-06-18 EP disclosed
US-6258507-B1 UNSATURATED AROMATIC ACRYLATED ESTER SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-07-10 US disclosed
EP-0945764-A2 Photoresist composition SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1999-09-29 EP disclosed
WO-1998037052-A1 PREPARATION OF ARYL BROMOARYL KETONES AND CARBOXYLIC DERIVATIVES THEREOF ALBEMARLE CORPORATION (US) 1998-08-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10144752-B2 Phosphinyl amidine compounds, metal complexes, catalyst systems, and their use to oligomerize or polymerize olefins NIT2, NCLN, NPM1 PPARA 2381/4885PPARG 4183/4885FABP2 4529/4885
US-20160168180-A1 Phosphinyl Amidine Compounds, Metal Complexes, Catalyst Systems, and Their Use to Oligomerize or Polymerize Olefins NIT2, NCLN, NPM1 PPARA 2381/4885PPARG 4183/4885FABP2 4529/4885
US-20170305945-A1 Phosphinyl Amidine Compounds, Metal Complexes, Catalyst Systems, and Their Use to Oligomerize or Polymerize Olefins NIT2, NCLN, NPM1 PPARA 2381/4885PPARG 4183/4885FABP2 4529/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.