Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 2/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6295378 | 0.80 | CES2 (0.48) | CES1CES2AKR1B1CNR2ALDH1A1 | |
| SCHEMBL2700591 | 0.78 | CES2 (0.46) | CES1CES2AKR1B1CNR2ALDH1A1 | |
| SCHEMBL8693468 | 0.78 | ALDH1A1 (0.42) | CES1CES2AKR1B1CNR2ALDH1A1 | |
| SCHEMBL6299815 | 0.76 | ALDH1A1 (0.44) | CES1CES2AKR1B1CNR2ALDH1A1 | |
| SCHEMBL1870609 | 0.76 | ALDH1A1 (0.62) | CES1CES2AKR1B1ALDH1A1KDM4E | |
| SCHEMBL16618549 | 0.76 | ALDH1A1 (0.49) | CES1CES2AKR1B1CNR2ALDH1A1 | |
| SCHEMBL13176469 | 0.76 | ALDH1A1 (0.44) | CES1CES2AKR1B1CNR2ALDH1A1 | |
| SCHEMBL7324968 | 0.76 | ALDH1A1 (0.45) | CES1CES2AKR1B1ALDH1A1KDM4E | |
| SCHEMBL6631326 | 0.76 | KMT2A (0.46) | CES1CES2AKR1B1CNR2ALDH1A1 | |
| SCHEMBL4675 | 0.76 | ALDH1A1 (0.62) | CES1CES2AKR1B1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 171 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018189199-A1 | PYRIDINIUM SALTS AND USES THEREOF | UNIVERSITY COLLEGE LONDON (GB) | 2018-10-18 | — | — | WO | claimed |
| CN-106957300-A | Antitumor (3 azelidinyls of heterocyclic drug intermediate 2）The synthetic method of pyridine dihydrochloride | 苏州汉德创宏生化科技有限公司 | 2017-07-18 | — | — | CN | claimed |
| CN-103709161-B | One-dimensional organic semiconductor nanowire with fluorescence and photoconduction dual response for organic amine gas as well as preparation method and application of nanowire | CHINESE ACAD INST CHEMISTRY | 2015-05-20 | — | — | CN | claimed |
| EP-2513064-A2 | COMPOUNDS, COMPOSITIONS AND METHODS FOR CONTROLLING BIOFILMS | Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) | 2012-10-24 | — | — | EP | claimed |
| WO-2011080132-A2 | COMPOUNDS, COMPOSITIONS AND METHODS FOR CONTROLLING BIOFILMS | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2011-07-07 | — | — | WO | claimed |
| US-20090060968-A1 | INHIBITORS OF PHOSPHATASES | SAUNDERS JEFFREY O | 2009-03-05 | — | — | US | claimed |
| EP-1620399-A1 | INDOLONE-ACETAMIDE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USES | UCB, S.A. (BE) | 2006-02-01 | — | — | EP | claimed |
| EP-1583747-A2 | INHIBITORS OF PHOSPHATASES | Vertex Pharmaceuticals Incorporated (US) | 2005-10-12 | — | — | EP | claimed |
| WO-2004087658-A1 | INDOLONE-ACETAMIDE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USES | UCB, S.A. (BE) | 2004-10-14 | — | — | WO | claimed |
| US-20040186116-A1 | such as 2-(7-acetylamino-1-furano-2-ylmethyl-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-succinic acid; for treatment of autoimmune diseases, proliferative diseases, angiogenic disorders, and/or cancers; catheters, prosthetics | VERTEX PHARMACEUTICALS INCORPORATED | 2004-09-23 | — | — | US | claimed |
| EP-0235111-A1 | Indolizine derivatives, process for their preparation and compositions containing them | SANOFI S.A. (FR) | 1987-09-02 | — | — | EP | claimed |
| EP-0081580-B1 | COMPOSITIONS FOR TREATING GLAUCOMA | AMERICAN HOSPITAL SUPPLY CORPORATION (US) | 1987-04-22 | — | — | EP | claimed |
| EP-0053436-B1 | METHOD FOR TREATMENT OR PROPHYLAXIS OF CARDIAC DISORDERS | AMERICAN HOSPITAL SUPPLY CORPORATION (US) | 1986-03-12 | — | — | EP | claimed |
| US-4501912-A | AMINO-2-HYDROXYROPYLBENZOATE COMPOUND OR SALT WITH LONG DURATION IN OCULAR FLUID; RAPID METABOLISM | AMERICAN HOSPITAL SUPPLY CORPORATION (US) | 1985-02-26 | — | — | US | claimed |
| EP-0034743-B1 | BENZOXAZOLES, THEIR PREPARATION AND THEIR USE AS MEDICINES | Dr. Karl Thomae GmbH (DE) | 1984-05-30 | — | — | EP | claimed |
| EP-0081580-A4 | COMPOSITIONS FOR TREATING GLAUCOMA. | AMERICAN HOSPITAL SUPPLY CORP (US) | 1983-12-01 | — | — | EP | claimed |
| US-4402974-A | WITH CARBOXY, OXY, CARBO-AMINE | AMERICAN HOSPITAL SUPPLY CORPORATION (US) | 1983-09-06 | — | — | US | claimed |
| EP-0081580-A1 | COMPOSITIONS FOR TREATING GLAUCOMA. | AMERICAN HOSPITAL SUPPLY CORP (US) | 1983-06-22 | — | — | EP | claimed |
| WO-1983000043-A1 | COMPOSITIONS FOR TREATING GLAUCOMA | AMERICAN HOSPITAL SUPPLY CORP (US) | 1983-01-06 | — | — | WO | claimed |
| US-4029650-A | VASODILATORS | DELALANDE S. A. (FR) | 1977-06-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090060968-A1 | INHIBITORS OF PHOSPHATASES | PPM1G, PPM1A, PPM1F | CES1 672/4885CES2 1279/4885AKR1B1 3527/4885 |
| US-20040186116-A1 | such as 2-(7-acetylamino-1-furano-2-ylmethyl-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-succinic acid; for treatment of autoimmune diseases, proliferative diseases, angiogenic disorders, and/or cancers; catheters, prosthetics | CD47, FGF1, FGF2 | CES1 3651/4885CES2 3176/4885AKR1B1 3408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.