SCHEMBL21546477

SCHEMBL21546477

Cc1ccc(-c2ccc3c4ccccc4n(-c4cc(C#N)cc(-n5c6ccccc6c6ccc(-c7ccc(C)cc7)cc65)c4-c4cccc(C#N)c4)c3c2)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MCHR1 Q99705 1/20 0.37
ALDH1A3 P47895 1/20 0.37
PDE9A O76083 1/20 0.36
PDE1C Q14123 1/20 0.36
GRIA2 P42262 1/20 0.36
GRIA4 P48058 1/20 0.36
PTPN5 P54829 1/20 0.36
TP53 P04637 1/20 0.35
MAPT P10636 1/20 0.35
HRH3 Q9Y5N1 1/20 0.35
PGR P06401 3/20 0.34
ALDH1A1 P00352 3/20 0.34
CYP1A2 P05177 3/20 0.34
CYP3A4 P08684 3/20 0.34
CLK4 Q9HAZ1 3/20 0.34
MEN1 O00255 2/20 0.34
CYP2C19 P33261 2/20 0.34
KMT2A Q03164 2/20 0.34
MAPK1 P28482 1/20 0.34
LMNA P02545 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21546479 0.95 GRIA2 (0.39) MCHR1ALDH1A3GRIA2GRIA4PTPN5
SCHEMBL21546727 0.94 MCHR1 (0.38) MCHR1ALDH1A3PDE9APDE1CGRIA2
SCHEMBL21546759 0.93 ALDH1A3 (0.39) ALDH1A3GRIA2GRIA4PTPN5TP53
SCHEMBL21414100 0.93 PDE9A (0.39) PDE9APDE1CTP53MAPTPGR
SCHEMBL21546578 0.93 ALDH1A3 (0.38) ALDH1A3GRIA2GRIA4PTPN5PGR
SCHEMBL22760890 0.92 ALDH1A3 (0.36) ALDH1A3GRIA2GRIA4PTPN5TP53
SCHEMBL21546747 0.92 PTPN5 (0.38) ALDH1A3GRIA2GRIA4PTPN5PGR
SCHEMBL21414161 0.92 ALDH1A3 (0.38) ALDH1A3GRIA2GRIA4PTPN5PGR
SCHEMBL22761029 0.91 PGR (0.34) MCHR1ALDH1A3PDE9APDE1CGRIA2
SCHEMBL21546788 0.91 ALDH1A3 (0.37) ALDH1A3GRIA2GRIA4PTPN5PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3478793-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2019-11-06 EP disclosed