SCHEMBL21546479

SCHEMBL21546479

Cc1ccc(-c2ccc3c4ccc(-c5ccc(C)cc5)cc4n(-c4cc(C#N)cc(-n5c6cc(-c7ccc(C)cc7)ccc6c6ccc(-c7ccc(C)cc7)cc65)c4-c4cccc(C#N)c4)c3c2)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRIA2 P42262 1/20 0.39
GRIA4 P48058 1/20 0.39
HRH3 Q9Y5N1 1/20 0.38
MCHR1 Q99705 1/20 0.37
PGR P06401 3/20 0.37
ALDH1A3 P47895 1/20 0.37
CLK4 Q9HAZ1 3/20 0.36
ALDH1A1 P00352 3/20 0.36
CYP1A2 P05177 3/20 0.36
CYP3A4 P08684 2/20 0.36
AR P10275 1/20 0.36
CHEK1 O14757 1/20 0.36
MAP4K4 O95819 1/20 0.36
PTPN5 P54829 1/20 0.36
XDH P47989 1/20 0.35
SLC22A12 Q96S37 1/20 0.35
TGFBR1 P36897 1/20 0.35
DYRK1A Q13627 1/20 0.35
MEN1 O00255 1/20 0.35
USP2 O75604 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21546477 0.95 MCHR1 (0.37) GRIA2GRIA4HRH3MCHR1PGR
SCHEMBL21546746 0.92 MAP4K4 (0.40) GRIA2GRIA4PGRALDH1A3CLK4
SCHEMBL21546984 0.92 GRM5 (0.37) GRIA2GRIA4PGRALDH1A3CLK4
SCHEMBL21546946 0.91 CYP1A2 (0.39) GRIA2GRIA4HRH3MCHR1PGR
SCHEMBL21546695 0.91 CLK4 (0.37) GRIA2GRIA4ALDH1A3CLK4ALDH1A1
SCHEMBL21546581 0.91 ALDH1A3 (0.41) GRIA2GRIA4PGRALDH1A3CLK4
SCHEMBL21414265 0.91 MAP4K4 (0.39) GRIA2GRIA4HRH3PGRALDH1A3
SCHEMBL21414101 0.91 ALDH1A1 (0.37) GRIA2GRIA4PGRALDH1A1AR
SCHEMBL21546786 0.90 MAP4K4 (0.39) GRIA2GRIA4PGRALDH1A3CLK4
SCHEMBL21928376 0.90 CHEK1 (0.39) HRH3MCHR1ALDH1A3CLK4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3478793-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2019-11-06 EP disclosed