Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 2/20 | 0.60 |
| ▸ | CXCR2 | P25025 | 17/20 | 0.49 |
| ▸ | CX3CR1 | P49238 | 4/20 | 0.46 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL841652 | 0.81 | CXCR2 (0.65) | PAK4CXCR2CX3CR1CXCR1 | |
| SCHEMBL212610 | 0.75 | PAK4 (1.00) | PAK4CXCR2CX3CR1 | |
| SCHEMBL6864829 | 0.73 | PAK4 (0.68) | PAK4CXCR2CX3CR1 | |
| SCHEMBL213220 | 0.72 | CXCR2 (0.61) | PAK4CXCR2CX3CR1 | |
| SCHEMBL6864835 | 0.71 | CXCR2 (0.61) | PAK4CXCR2CX3CR1CXCR1 | |
| SCHEMBL23111558 | 0.68 | PAK4 (0.58) | PAK4CXCR2CX3CR1 | |
| SCHEMBL1588616 | 0.68 | PAK4 (0.58) | PAK4CXCR2CX3CR1 | |
| SCHEMBL843318 | 0.68 | CXCR2 (0.50) | PAK4CXCR2CX3CR1CXCR1 | |
| SCHEMBL6869012 | 0.68 | PAK4 (0.77) | PAK4CXCR2CX3CR1 | |
| SCHEMBL842363 | 0.66 | CXCR2 (1.00) | CXCR2CX3CR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088780-B2 | 5,7-disubstituted thiazolo[4,5-D]pyrimidines for the selective inhibition of chemokine receptors | ASTRAZENECA AB (SE) | 2012-01-03 | — | — | US | disclosed |
| US-20090124637-A1 | Novel 5,7-Disubstituted [1,3]Thiazolo[4,5-D]Pyrimidin-2(3H)-One Derivatives 794 | ASTRAZENECA AB (SE) | 2009-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124637-A1 | Novel 5,7-Disubstituted [1,3]Thiazolo[4,5-D]Pyrimidin-2(3H)-One Derivatives 794 | CX3CR1, CCR2, CCR5 | PAK4 1612/4885CXCR2 5/4885CX3CR1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.