Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CCR4 | P51679 | 1/20 | 0.39 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MGMT | P16455 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21548812 | 0.90 | SMN1; SMN2 (0.44) | SMN1; SMN2KDM4EMAPTALDH1A1LMNA | |
| SCHEMBL21526079 | 0.83 | GPR132 (0.44) | SMN1; SMN2CCR4GPR132HTR1ADRD2 | |
| SCHEMBL21548831 | 0.82 | SMN1; SMN2 (0.41) | SMN1; SMN2MAPTALDH1A1LMNAHTT | |
| SCHEMBL21548960 | 0.81 | SMN1; SMN2 (0.43) | SMN1; SMN2MEN1KMT2AKDM4EMAPT | |
| SCHEMBL23956006 | 0.77 | MAPK14 (0.39) | SMN1; SMN2MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL23956005 | 0.75 | SMN1; SMN2 (0.42) | SMN1; SMN2KDM4EMAPTALDH1A1LMNA | |
| SCHEMBL20356576 | 0.72 | SMN1; SMN2 (0.44) | SMN1; SMN2MAPTALDH1A1LMNAENPP1 | |
| SCHEMBL21526094 | 0.72 | SMN1; SMN2 (0.40) | SMN1; SMN2MEN1KMT2AKDM4EMAPT | |
| SCHEMBL20356567 | 0.71 | SMN1; SMN2 (0.41) | SMN1; SMN2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL21548830 | 0.69 | SMN1; SMN2 (0.38) | SMN1; SMN2MEN1KMT2AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3564216-B1 | PYRIMIDINE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2021-10-27 | — | — | EP | disclosed |
| EP-3564216-A1 | PYRIMIDINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2019-11-06 | — | — | EP | disclosed |