Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21548856 | 0.88 | HTT (0.40) | HTTSMN1; SMN2ALDH1A1LMNAHPGD | |
| SCHEMBL20356511 | 0.84 | ALDH1A1 (0.46) | HTTALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL20356578 | 0.74 | SMN1; SMN2 (0.44) | HTTSMN1; SMN2P2RX7MAPTKDM4E | |
| SCHEMBL20356656 | 0.74 | P2RX7 (0.40) | HTTALDH1A1LMNAHPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL21526059 | 0.73 | P2RX7 (0.40) | HTTALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL23955999 | 0.73 | SMN1; SMN2 (0.48) | HTTSMN1; SMN2ALDH1A1LMNAHPGD | |
| SCHEMBL21548807 | 0.72 | SMN1; SMN2 (0.47) | HTTSMN1; SMN2ALDH1A1LMNAHPGD | |
| SCHEMBL21548891 | 0.72 | SMN1; SMN2 (0.73) | HTTSMN1; SMN2ALDH1A1LMNAP2RX7 | |
| SCHEMBL20356569 | 0.71 | ALDH1A1 (0.49) | HTTALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL21548875 | 0.70 | ALDH1A1 (0.47) | SMN1; SMN2ALDH1A1LMNAPOLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3564216-B1 | PYRIMIDINE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2021-10-27 | — | — | EP | disclosed |
| EP-3564216-A1 | PYRIMIDINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2019-11-06 | — | — | EP | disclosed |