Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.35 |
| ▸ | PYGL | P06737 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21564741 | 0.83 | ABL1 (0.33) | SLC6A2 | |
| SCHEMBL20157925 | 0.79 | ALDH1A1 (0.36) | APLNRMDM2MAPTPKMSLC6A2 | |
| SCHEMBL21550145 | 0.77 | MDM2 (0.33) | APLNRMDM2PKMFDFT1 | |
| SCHEMBL28473298 | 0.76 | MDM2 (0.46) | PYGLMDM2 | |
| SCHEMBL21550101 | 0.76 | APLNR (0.38) | APLNRFDFT1 | |
| SCHEMBL21550122 | 0.75 | ALDH1A1 (0.41) | APLNRMDM2PKMFDFT1 | |
| SCHEMBL21564721 | 0.74 | MDM2 (0.30) | MDM2 | |
| SCHEMBL21550018 | 0.72 | MDM2 (0.49) | NPC1RAB9AMDM2MEN1MAPT | |
| SCHEMBL28476113 | 0.72 | MDM2 (0.39) | APLNRRAB9AMDM2MEN1KMT2A | |
| SCHEMBL21564723 | 0.71 | MDM2 (0.31) | MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019214399-A1 | BENZO- SEVEN-MEMBERED HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND APPLICATION THEREOF | 罗欣药业(上海)有限公司 (CN) | 2019-11-14 | — | — | WO | disclosed |