SCHEMBL21550134

SCHEMBL21550134

COC(=O)Cc1cc[nH]c(=O)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.49
GAA P10253 1/20 0.49
GFER P55789 1/20 0.49
HSP90AB1 P08238 1/20 0.49
CYP4F2 P78329 1/20 0.46
CYP4A11 Q02928 1/20 0.46
SLC7A5 Q01650 1/20 0.43
TSHR P16473 2/20 0.42
HPGD P15428 2/20 0.42
MAPT P10636 1/20 0.42
HPGDS O60760 1/20 0.42
ALDH2 P05091 4/20 0.40
BRD4 O60885 1/20 0.40
SMN1; SMN2 Q16637 3/20 0.39
NPC1 O15118 2/20 0.39
RAB9A P51151 2/20 0.39
PDK2 Q15119 1/20 0.39
PKM P14618 1/20 0.39
NFKB1 P19838 1/20 0.39
NFKB2 Q00653 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22230129 0.83 PTPN1 (0.43) ALDH1A1TSHRHPGDMAPTHPGDS
SCHEMBL4161939 0.83 SMN1; SMN2 (0.49) ALDH1A1GAACYP4F2CYP4A11HPGD
SCHEMBL4604293 0.77 CA2 (0.44) ALDH1A1ALDH2NSD2ABL1PPARG
SCHEMBL16180236 0.76 HDAC1 (0.53) ALDH1A1GAAGFERHSP90AB1CYP4F2
SCHEMBL11976503 0.76 NLRP3 (0.53) ALDH1A1GAAGFERHSP90AB1CYP4F2
SCHEMBL22230057 0.74 HPGDS (0.39) HPGDSALDH2NSD2ABL1PPARG
SCHEMBL5739617 0.74 CYP4F2 (0.51) ALDH1A1GAAGFERHSP90AB1CYP4F2
SCHEMBL18460841 0.74 NSD2 (0.36) HPGDSALDH2NSD2ABL1PPARG
SCHEMBL12400239 0.74 SLC7A5 (0.68) ALDH1A1GAAGFERHSP90AB1CYP4F2
SCHEMBL8168734 0.73 CYP4A11 (0.43) ALDH1A1GAACYP4F2CYP4A11HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111819181-A Benzo-seven-membered heterocyclic compound, preparation method, pharmaceutical composition and application thereof 罗欣药业(上海)有限公司 2020-10-23 CN disclosed
WO-2019214399-A1 BENZO- SEVEN-MEMBERED HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND APPLICATION THEREOF 罗欣药业(上海)有限公司 (CN) 2019-11-14 WO disclosed
WO-2019214399-A1 BENZO- SEVEN-MEMBERED HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND APPLICATION THEREOF 罗欣药业(上海)有限公司 (CN) 2019-11-14 WO disclosed