Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21552627 | 1.00 | GPR119 (0.36) | GPR119L3MBTL1GABRDGABRA1GABRB1 | |
| SCHEMBL21552625 | 0.81 | ALDH1A1 (0.34) | L3MBTL1STAT3ALDH1A1HPGDNPSR1 | |
| SCHEMBL21552586 | 0.81 | ALDH1A1 (0.34) | L3MBTL1STAT3ALDH1A1HPGDNPSR1 | |
| SCHEMBL23364110 | 0.81 | ALDH1A1 (0.34) | L3MBTL1STAT3ALDH1A1HPGDNPSR1 | |
| SCHEMBL23364356 | 0.80 | GPR119 (0.36) | GPR119L3MBTL1STAT3ALDH1A1HPGD | |
| SCHEMBL23364540 | 0.80 | GPR119 (0.36) | GPR119L3MBTL1STAT3ALDH1A1HPGD | |
| SCHEMBL2389377 | 0.76 | ALDH1A1 (0.45) | GPR119STAT3ALDH1A1KDM4ECYP2D6 | |
| SCHEMBL23364149 | 0.75 | CYP2D6 (0.37) | L3MBTL1STAT3ALDH1A1HPGDNPSR1 | |
| SCHEMBL23364148 | 0.75 | CYP2D6 (0.37) | L3MBTL1STAT3ALDH1A1HPGDNPSR1 | |
| SCHEMBL23364538 | 0.75 | HTR7 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3790859-A1 | NOVEL FUNCTIONALIZED LACTAMS AS MODULATORS OF THE 5-HYDROXYTRYPTAMINE RECEPTOR 7 AND THEIR METHOD OF USE | Temple University - Of The Commonwealth System of Higher Education (US) | 2021-03-17 | — | — | EP | disclosed |
| WO-2019217890-A1 | NOVEL FUNCTIONALIZED LACTAMS AS MODULATORS OF THE 5-HYDROXYTRYPTAMINE RECEPTOR 7 AND THEIR METHOD OF USE | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2019-11-14 | — | — | WO | disclosed |