Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 4/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12621125 | 0.86 | PDK1 (0.36) | PDK1PDK2PDK3 | |
| SCHEMBL1806182 | 0.78 | PDK1 (0.37) | PDK1PDK2PDK3 | |
| SCHEMBL25125561 | 0.77 | PDK1 (0.39) | PDK1PDK2PDK3 | |
| SCHEMBL890074 | 0.77 | PDK1 (0.39) | PDK1PDK2PDK3 | |
| SCHEMBL21430670 | 0.75 | L3MBTL1 (0.36) | PDK1PDK2PDK3 | |
| SCHEMBL25808422 | 0.75 | PDK1 (0.39) | PDK1PDK2PDK3 | |
| SCHEMBL25808421 | 0.75 | PDK1 (0.39) | PDK1PDK2PDK3 | |
| SCHEMBL17778486 | 0.74 | PDK1 (0.51) | PDK1PDK2PDK3 | |
| Hydrochloric Acid SCHEMBL31393754 | 0.74 | PDK1 (0.37) | PDK1PDK2PDK3 | |
| SCHEMBL24630698 | 0.74 | PDK1 (0.51) | PDK1PDK2PDK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11154563-B2 | Immunoproteasome inhibitors | PRINCIPIA BIOPHARMA INC. (US) | 2021-10-26 | — | — | US | disclosed |
| US-20190336515-A1 | IMMUNOPROTEASOME INHIBITORS | PRINCIPIA BIOPHARMA INC. | 2019-11-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11154563-B2 | Immunoproteasome inhibitors | PSMC2, PSMB7, PSMB2 | PDK1 4072/4885PDK2 3019/4885PDK3 3937/4885 |
| US-20190336515-A1 | IMMUNOPROTEASOME INHIBITORS | PSMC2, PSMB7, PSMB2 | PDK1 4072/4885PDK2 3019/4885PDK3 3937/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.