Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 3/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA3 | P07451 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16252315 | 0.90 | FAAH (0.40) | ROCK1DGAT1HIF1ABACE1CA1 | |
| SCHEMBL795588 | 0.86 | KDM4E (0.42) | KMT2AROCK1HIF1APRMT5WDR77 | |
| SCHEMBL2556943 | 0.82 | CA1 (0.39) | ROCK1HIF1ACA1CA2CA9 | |
| SCHEMBL31394640 | 0.79 | BACE1 (0.43) | ROCK1BACE1CA1CA2CA9 | |
| SCHEMBL31393926 | 0.79 | BACE1 (0.43) | ROCK1BACE1CA1CA2CA9 | |
| SCHEMBL16100403 | 0.79 | LIPG (0.41) | ROCK1BACE1BACE2CA1CA2 | |
| SCHEMBL20563166 | 0.79 | POLB (0.37) | ROCK1DGAT1HIF1APRMT5WDR77 | |
| SCHEMBL28442898 | 0.78 | ROCK1 (0.40) | ROCK1HIF1APRMT5WDR77BACE1 | |
| SCHEMBL15096664 | 0.77 | LIPG (0.42) | ROCK1BACE1CA1CA2CA9 | |
| SCHEMBL15100254 | 0.77 | PRMT5 (0.46) | ROCK1DGAT1HIF1APRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10647710-B2 | Thiazole derivative and applications thereof | MEDSHINE DISCOVERY INC. (CN) | 2020-05-12 | — | — | US | disclosed |
| EP-3566749-A1 | THIAZOLE DERIVATIVE AND APPLICATIONS THEREOF | Medshine Discovery Inc. (CN) | 2019-11-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10647710-B2 | Thiazole derivative and applications thereof | TSLP, TK2, TK1 | KMT2A 4236/4885ROCK1 4574/4885DGAT1 3877/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.