SCHEMBL21562376

SCHEMBL21562376

C(\CCc1ccccc1)=N/c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.41
ALDH1A1 P00352 1/20 0.41
HPGD P15428 1/20 0.41
ALOX15 P16050 1/20 0.41
ALOX12 P18054 1/20 0.41
CASP1 P29466 1/20 0.41
HSD17B10 Q99714 1/20 0.41
GAA P10253 1/20 0.40
MAPT P10636 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
TDP1 Q9NUW8 2/20 0.39
CYP2A6 P11509 1/20 0.39
HTR2A P28223 1/20 0.39
TAAR1 Q96RJ0 1/20 0.39
LOXL2 Q9Y4K0 1/20 0.39
GPR52 Q9Y2T5 2/20 0.39
CYP2C9 P11712 1/20 0.39
MAOA P21397 1/20 0.37
MAOB P27338 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10763352 1.00 SMN1; SMN2 (0.41) SMN1; SMN2ALDH1A1HPGDALOX15ALOX12
SCHEMBL10759775 0.87 PTGS2 (0.43) SMN1; SMN2ALDH1A1ALOX12GAATAAR1
SCHEMBL11777039 0.79 SMN1; SMN2 (0.49) SMN1; SMN2ALDH1A1HPGDALOX15ALOX12
SCHEMBL11777041 0.79 SMN1; SMN2 (0.49) SMN1; SMN2ALDH1A1HPGDALOX15ALOX12
SCHEMBL10764942 0.79 GPR52 (0.50) ALDH1A1HSD17B10MAPTTDP1TAAR1
SCHEMBL18947039 0.77 MAOB (0.50) ALDH1A1MAPTLOXL2CYP2C9MAOA
SCHEMBL2342516 0.77 MAOB (0.50) ALDH1A1MAPTLOXL2CYP2C9MAOA
SCHEMBL12136378 0.77 MAOB (0.50) ALDH1A1MAPTLOXL2CYP2C9MAOA
SCHEMBL7516473 0.76 ALDH1A1 (0.45) SMN1; SMN2ALDH1A1ALOX12GAAMAPT
SCHEMBL10090559 0.76 ALDH1A1 (0.45) SMN1; SMN2ALDH1A1ALOX12GAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019215426-A1 PROCESS FOR FORMING A CARBON-CARBON BOND THE UNIVERSITY OF MANCHESTER (GB) 2019-11-14 WO disclosed