Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 7/20 | 0.34 |
| ▸ | GABRD | O14764 | 7/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 7/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 7/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 7/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 7/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 7/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 7/20 | 0.34 |
| ▸ | GABRE | P78334 | 7/20 | 0.34 |
| ▸ | GABRA6 | Q16445 | 7/20 | 0.34 |
| ▸ | GABRG1 | Q8N1C3 | 7/20 | 0.34 |
| ▸ | GABRG3 | Q99928 | 7/20 | 0.34 |
| ▸ | GABRQ | Q9UN88 | 7/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18325701 | 0.91 | GABRP (0.35) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL21549872 | 0.82 | MEN1 (0.33) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL21563100 | 0.77 | HDAC9 (0.34) | MEN1GAAKMT2AKDM4EALDH1A1 | |
| SCHEMBL18209727 | 0.73 | GABRP (0.41) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL21563050 | 0.71 | HDAC9 (0.34) | GAAALDH1A1 | |
| SCHEMBL23646937 | 0.68 | MAPK1 (0.38) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL14487500 | 0.68 | TRPM2 (0.46) | GAAALDH1A1NPSR1 | |
| SCHEMBL21995862 | 0.67 | GABRP (0.37) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL21562959 | 0.66 | RORC (0.39) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL18854207 | 0.65 | LMNA (0.39) | MEN1GAAKMT2AALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210220356-A1 | DIHYDROPYRIMIDINE DERIVATIVES AND USES THEREOF IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES | Janssen Sciences Ireland Unlimited Company (IE) | 2021-07-22 | — | — | US | disclosed |
| WO-2019214610-A1 | DIHYDROPYRIMIDINE DERIVATIVES AND USES THEREOF IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES | Janssen Sciences Ireland Unlimited Company (IE) | 2019-11-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210220356-A1 | DIHYDROPYRIMIDINE DERIVATIVES AND USES THEREOF IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES | DPYD, TYMP, HAVCR2 | GABRP 1441/4885GABRD 1059/4885GABRA1 2854/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.