Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | AKT1 | P31749 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | DDX3X | O00571 | 1/20 | 0.32 |
| ▸ | MBOAT4 | Q96T53 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.30 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.30 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.30 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.30 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21553086 | 0.82 | GABRA2 (0.39) | PFKFB3LMNAKDM4EHSD17B10MAPT | |
| SCHEMBL21564763 | 0.82 | LMNA (0.37) | LMNAKDM4EALDH1A1MAPTL3MBTL1 | |
| SCHEMBL21553095 | 0.79 | PFKFB3 (0.37) | PFKFB3LMNAKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL21553066 | 0.78 | PTGS2 (0.41) | PFKFB3ALDH1A1SYK | |
| SCHEMBL21552964 | 0.77 | PFKFB3 (0.38) | PFKFB3LMNAKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL21564616 | 0.67 | POLB (0.43) | LMNAKDM4EHSD17B10ALDH1A1AKT1 | |
| SCHEMBL21564466 | 0.64 | AKT1 (0.40) | LMNAALDH1A1AKT1HTTL3MBTL1 | |
| SCHEMBL21564780 | 0.64 | GABRA2 (0.43) | LMNAKDM4EHSD17B10ALDH1A1MAPT | |
| SCHEMBL23387322 | 0.61 | LIPE (0.48) | PFKFB3LMNAKDM4EALDH1A1AKT1 | |
| SCHEMBL21564592 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019217972-A1 | KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE | IMAGO BIOSCIENCES, INC. (US) | 2019-11-14 | — | — | WO | disclosed |