Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.60 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.60 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.60 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 7/20 | 0.57 |
| ▸ | RAB9A | P51151 | 7/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.57 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.56 |
| ▸ | SCD | O00767 | 1/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.55 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 5/20 | 0.55 |
| ▸ | LMNA | P02545 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.55 |
| ▸ | RELA | Q04206 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21568117 | 0.83 | DYRK1A (0.60) | HTTNPC1RAB9ASMN1; SMN2DYRK1A | |
| SCHEMBL31637616 | 0.83 | PIK3CA (0.59) | PIK3CAPIK3CBPIK3CGPI4KBHTT | |
| SCHEMBL21568693 | 0.78 | DYRK1A (0.55) | PIK3CAPIK3CGHTTNPC1RAB9A | |
| SCHEMBL21568314 | 0.77 | LDHA (0.61) | HTTNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL21568155 | 0.76 | SMN1; SMN2 (0.66) | HTTNPC1RAB9ASMN1; SMN2DYRK1A | |
| SCHEMBL23357 | 0.75 | RAB9A (0.84) | HTTNPC1RAB9ASMN1; SMN2SCD | |
| SCHEMBL21568136 | 0.74 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2DYRK1ADYRK1B | |
| SCHEMBL19202176 | 0.73 | PIK3CA (0.75) | PIK3CAPIK3CBPIK3CGPI4KBHTT | |
| SCHEMBL5534541 | 0.73 | HTT (1.00) | PIK3CAPIK3CBPIK3CGPI4KBHTT | |
| SCHEMBL15427000 | 0.73 | NPC1 (1.00) | PIK3CAPIK3CBPIK3CGPI4KBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019217509-A1 | COMPOSITIONS AND METHODS FOR TREATING CANCER | HB THERAPEUTICS INC. (US) | 2019-11-14 | — | — | WO | disclosed |