Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 11/20 | 0.40 |
| ▸ | NOS2 | P35228 | 8/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20826204 | 0.87 | NOS2 (0.39) | RORCNOS2IDH1 | |
| SCHEMBL23098147 | 0.84 | RORC (0.37) | RORCNOS2IDH1 | |
| SCHEMBL24035554 | 0.80 | NOS2 (0.37) | RORCNOS2 | |
| SCHEMBL21085449 | 0.80 | NOS2 (0.38) | RORCNOS2 | |
| SCHEMBL21573981 | 0.80 | NOS2 (0.38) | RORCNOS2 | |
| SCHEMBL20925572 | 0.78 | MBOAT4 (0.39) | RORCNOS2 | |
| SCHEMBL21085388 | 0.78 | NOS2 (0.51) | RORCNOS2 | |
| SCHEMBL20925551 | 0.77 | MBOAT4 (0.38) | RORCNOS2 | |
| SCHEMBL23098217 | 0.77 | NOS2 (0.40) | RORCNOS2 | |
| SCHEMBL23098149 | 0.76 | NOS2 (0.41) | RORCNOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558105-B1 | BARDOXOLONE METHYL FOR THE TREATMENT OF OBESITY | REATA PHARMACEUTICALS INC (US) | 2019-11-20 | — | — | EP | disclosed |