Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.46 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | THRA | P10827 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19910455 | 0.90 | L3MBTL1 (0.50) | L3MBTL1SLC6A9KDM4EALDH1A1THRA | |
| SCHEMBL19910374 | 0.81 | KDM4E (0.46) | L3MBTL1SLC6A9KDM4EALDH1A1THRA | |
| SCHEMBL30765139 | 0.79 | PARP10 (0.68) | PARP15PARP10MAOBPARP14ALDH1A1 | |
| SCHEMBL19910396 | 0.78 | L3MBTL1 (0.61) | L3MBTL1KDM4EALDH1A1THRATHRB | |
| SCHEMBL2087136 | 0.76 | MAOB (0.64) | L3MBTL1PARP15PARP10MAOBPARP14 | |
| SCHEMBL19910479 | 0.76 | LPAR1 (0.55) | PARP15PARP10MAOBPARP14KDM4E | |
| SCHEMBL30151541 | 0.73 | MAPK1 (0.50) | KDM4EALDH1A1THRATHRBKMT2A | |
| SCHEMBL28897893 | 0.73 | LPAR1 (0.43) | L3MBTL1KDM4ETHRATHRBMEN1 | |
| SCHEMBL6305137 | 0.73 | MAPK1 (0.45) | PARP15PARP10MAOBPARP14THRA | |
| Hydrochloric Acid SCHEMBL30460803 | 0.72 | MAPK1 (0.44) | THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3288948-B1 | FUSED TRICYCLIC PYRAZOLE DERIVATIVES USEFUL FOR MODULATING FARNESOID X RECEPTORS | NOVARTIS AG (CH) | 2019-11-20 | — | — | EP | disclosed |