Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 7/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16633163 | 0.86 | RORC (0.38) | RORCRXFP1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL16662148 | 0.76 | RORC (0.56) | PKMELANERORCRXFP1CYP1A2 | |
| SCHEMBL16632876 | 0.75 | RORC (0.44) | RORC | |
| SCHEMBL16632926 | 0.72 | ALDH1A1 (0.44) | RORCCYP1A2CYP2C9CYP2C19LMNA | |
| SCHEMBL5085893 | 0.67 | LMNA (0.54) | PKMELANELMNAMAPTKDM4E | |
| SCHEMBL14044130 | 0.67 | CYP1A2 (0.72) | PKMELANERXFP1CYP1A2CYP2D6 | |
| SCHEMBL16632741 | 0.65 | RORC (0.42) | PKMRORCRXFP1CYP1A2CYP2D6 | |
| SCHEMBL9593290 | 0.65 | LMNA (0.62) | PKMELANECYP1A2LMNAMAPT | |
| SCHEMBL16656034 | 0.64 | RORC (0.67) | RORC | |
| SCHEMBL27138975 | 0.64 | LMNA (0.49) | ELANELMNAMAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057951-B1 | METHYLENE LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T | JANSSEN PHARMACEUTICA NV (BE) | 2019-11-20 | — | — | EP | disclosed |