Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 10/20 | 0.44 |
| ▸ | PDE8B | O95263 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | FNTA | P49354 | 1/20 | 0.40 |
| ▸ | FNTB | P49356 | 1/20 | 0.40 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | PKLR | P30613 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30469042 | 0.82 | NPBWR1 (0.54) | NPBWR1MCHR1PKMPKLR | |
| SCHEMBL20176889 | 0.81 | NPBWR1 (0.47) | NPBWR1MCHR1PKMPKLRCYP11B1 | |
| SCHEMBL3356641 | 0.78 | NPBWR1 (0.49) | NPBWR1PDE8BMCHR1PKMPKLR | |
| SCHEMBL30515984 | 0.77 | PDE8B (0.46) | NPBWR1PDE8BMCHR1FNTAFNTB | |
| SCHEMBL29063941 | 0.77 | PDE8B (0.46) | NPBWR1PDE8BMCHR1FNTAFNTB | |
| SCHEMBL30051137 | 0.77 | NPBWR1 (0.46) | NPBWR1MCHR1UCHL1KDM4E | |
| SCHEMBL16014455 | 0.76 | KMT2A (0.54) | NPBWR1PDE8BMCHR1PKMKDM4E | |
| SCHEMBL30050968 | 0.76 | NPBWR1 (0.43) | NPBWR1PDE8BMCHR1PKMPKLR | |
| SCHEMBL29023088 | 0.76 | NPBWR1 (0.43) | NPBWR1PDE8BMCHR1PKMPKLR | |
| SCHEMBL30408409 | 0.76 | NPBWR1 (0.46) | NPBWR1MCHR1CYP11B1CYP11B2UCHL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190352276-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | JOINT STOCK COMPANY "BIOCAD" (RU) | 2019-11-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190352276-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | BTK, ABL1, CNKSR1 | NPBWR1 396/4885PDE8B 2144/4885MCHR1 995/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.