Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.51 |
| ▸ | UBE2N | P61088 | 1/20 | 0.47 |
| ▸ | APAF1 | O14727 | 2/20 | 0.44 |
| ▸ | CASP6 | P55212 | 2/20 | 0.44 |
| ▸ | CASP8 | Q14790 | 2/20 | 0.44 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | GPR6 | P46095 | 1/20 | 0.39 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.39 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL8411385 | 0.88 | ALDH1A1 (0.48) | PABPC1ALDH1A1NPC1MEN1POLB | |
| Quinoline SCHEMBL3872200 | 0.83 | ALDH1A1 (0.63) | L3MBTL1UBE2NPABPC1ALDH1A1NPC1 | |
| Quinoline SCHEMBL5874750 | 0.83 | ALDH1A1 (0.63) | L3MBTL1UBE2NPABPC1ALDH1A1NPC1 | |
| SCHEMBL30917351 | 0.82 | ALDH1A1 (0.58) | ALDH1A1NPC1MEN1POLBMAPT | |
| SCHEMBL30087475 | 0.82 | ALDH1A1 (0.58) | ALDH1A1NPC1MEN1POLBMAPT | |
| SCHEMBL139749 | 0.82 | ALDH1A1 (0.58) | ALDH1A1NPC1MEN1POLBMAPT | |
| Trifluoroacetic Acid SCHEMBL30391689 | 0.82 | EGFR (0.43) | L3MBTL1UBE2NAPAF1CASP6CASP8 | |
| Trifluoroacetic Acid SCHEMBL29977443 | 0.82 | EGFR (0.43) | L3MBTL1UBE2NAPAF1CASP6CASP8 | |
| Formaldehyde SCHEMBL27816605 | 0.81 | ALDH1A1 (0.52) | ALDH1A1NPC1MEN1POLBMAPT | |
| Hydrochloric Acid SCHEMBL3326679 | 0.80 | ALDH1A1 (0.56) | ALDH1A1NPC1MEN1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110183974-A1 | 1,2,4-OXADIAZOLE SUBSTITUTED PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS | INSTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI (IT) | 2011-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110183974-A1 | 1,2,4-OXADIAZOLE SUBSTITUTED PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS | SHH, SMO, GLI1 | L3MBTL1 3642/4885UBE2N 3702/4885APAF1 3785/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.