Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.48 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.45 |
| ▸ | UBE2N | P61088 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MGAM | O43451 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinoline SCHEMBL5874750 | 1.00 | ALDH1A1 (0.63) | ALDH1A1L3MBTL1PABPC1UBE2NMAPT | |
| Quinoline SCHEMBL5527084 | 0.95 | ALDH1A1 (0.57) | ALDH1A1L3MBTL1PABPC1UBE2NMAPT | |
| Trifluoroacetic Acid SCHEMBL22397327 | 0.88 | L3MBTL1 (0.45) | ALDH1A1L3MBTL1UBE2NMAPTSMN1; SMN2 | |
| Quinoline SCHEMBL5874587 | 0.87 | ALDH1A1 (0.65) | ALDH1A1PABPC1MAPTSMN1; SMN2MEN1 | |
| Quinoline SCHEMBL28970061 | 0.86 | ALDH1A1 (0.71) | ALDH1A1PABPC1MAPTSMN1; SMN2MEN1 | |
| Quinoline SCHEMBL5874493 | 0.86 | ALDH1A1 (0.77) | ALDH1A1PABPC1MAPTSMN1; SMN2MEN1 | |
| Quinoline SCHEMBL372690 | 0.86 | ALDH1A1 (0.77) | ALDH1A1PABPC1MAPTSMN1; SMN2MEN1 | |
| Quinoline SCHEMBL5283313 | 0.86 | ALDH1A1 (0.77) | ALDH1A1PABPC1MAPTSMN1; SMN2MEN1 | |
| Quinoline SCHEMBL5875384 | 0.84 | ALDH1A1 (0.74) | ALDH1A1PABPC1MAPTSMN1; SMN2MEN1 | |
| Quinoline SCHEMBL5272119 | 0.84 | ALDH1A1 (0.74) | ALDH1A1PABPC1MAPTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11312713-B2 | Imidazo[4,5-C]quinoline derivatives as LRRK2 inhibitors | PFIZER INC. (US) | 2022-04-26 | — | — | US | disclosed |
| CN-106536502-B | The phenyl tetrahydro isoquinoline compound being substituted by heteroaryl | 大正制药株式会社 | 2019-03-05 | — | — | CN | disclosed |
| CN-106536502-A | Phenyl tetrahydroisoquinoline compound substituted with heteroaryl | 大正制药株式会社 | 2017-03-22 | — | — | CN | disclosed |
| CN-102985411-B | Imaging agents for detecting neurological disorders | ELI LILLY AND CO. (US) | 2016-02-10 | — | — | CN | disclosed |
| CN-104995191-A | Tricyclic quinoline and quinoxaline derivatives | ABBVIE DEUTSCHLAND | 2015-10-21 | — | — | CN | disclosed |
| CN-101594866-B | Topical formulations | HELPERBY THERAPEUTICS LTD. (GB) | 2014-10-22 | — | — | CN | disclosed |
| CN-101351203-B | Application of pyrroloquinoline compound in killing clinically latent microorganisms | HELPERBY THERAPEUTICS LTD | 2013-12-04 | — | — | CN | disclosed |
| CN-102186851-B | Triazolopyridine compounds as pim kinase inhibitors | ARRAY BIOPHARMA INC | 2013-06-12 | — | — | CN | disclosed |
| CN-102438660-A | Imaging agents for detecting neurological disorders | SIEMENS MEDICAL SOLUTIONS | 2012-05-02 | — | — | CN | disclosed |
| CN-102186851-A | Triazolopyridine compounds as pim kinase inhibitors | ARRAY BIOPHARMA INC | 2011-09-14 | — | — | CN | disclosed |
| WO-2007054693-A1 | USE OF PYRROLOQUINOLINE COMPOUNDS TO KILL CLINICALLY LATENT MICROORGANISMS | HELPERBY THERAPEUTICS LIMITED (GB) | 2007-05-18 | — | — | WO | disclosed |
| CN-1910149-A | Bronchodilatory compounds | RESPIRATORIUS AB (SE) | 2007-02-07 | — | — | CN | disclosed |
| CN-1897948-A | Alkoxy substituted imidazoquinolines | 3M INNOVATIVE PROPERTIES CO (US) | 2007-01-17 | — | — | CN | disclosed |
| CN-1809360-A | 4-anilino-quinazoline derivatives as antiproliferative agents | ASTRAZENECA AB (SE) | 2006-07-26 | — | — | CN | disclosed |
| CN-1261099-C | Tetrahydroquinoline derivatives | AKZO NOBEL NV (NL) | 2006-06-28 | — | — | CN | disclosed |
| CN-1764651-A | Quinazoline derivatives as antitumor agents | ASTRAZENECA AB (SE) | 2006-04-26 | — | — | CN | disclosed |
| CN-1529601-A | Tetrahydroquinoline derivatives | ��˹��ŵ�� | 2004-09-15 | — | — | CN | disclosed |
| CN-1323307-A | 1H-imidazopyridine derivatives | HOKURIKU SEIYAKU (JP) | 2001-11-21 | — | — | CN | disclosed |
| EP-1140946-A2 | QUINOLINE DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035919-A2 | QUINOLINE DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 2000-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11312713-B2 | Imidazo[4,5-C]quinoline derivatives as LRRK2 inhibitors | LRRK2, PARK7, BRCA1 | ALDH1A1 1569/4885L3MBTL1 108/4885PABPC1 4737/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.