Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.39 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21580113 | 0.90 | SCN3A (0.48) | TP53LMNAPARP15PARP10MAOB | |
| SCHEMBL21580066 | 0.89 | TP53 (0.47) | TP53LMNASCN3AALDH1A1HPGD | |
| SCHEMBL21580082 | 0.86 | KDM4E (0.43) | TP53LMNAPARP15PARP10MAOB | |
| SCHEMBL23691881 | 0.83 | LMNA (0.42) | TP53LMNAPARP15PARP10MAOB | |
| SCHEMBL21580078 | 0.83 | LMNA (0.45) | TP53LMNAPARP15PARP10MAOB | |
| SCHEMBL21580093 | 0.83 | RIPK1 (0.37) | TP53PARP15PARP10KLKB1THRB | |
| SCHEMBL21580081 | 0.80 | MAPT (0.43) | TP53LMNAPARP15PARP10MAOB | |
| SCHEMBL21580146 | 0.79 | PARP15 (0.45) | TP53LMNAPARP15PARP10MAOB | |
| SCHEMBL21580138 | 0.76 | SCN3A (0.49) | TP53LMNAPARP15PARP10MAOB | |
| SCHEMBL21580033 | 0.75 | KDM4E (0.41) | TP53LMNASCN3AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11384085-B2 | Modulators of ion channel receptors and uses thereof | BIONOMICS LIMITED (AU) | 2022-07-12 | — | — | US | disclosed |
| US-20210230165-A1 | MODULATORS OF ION CHANNEL RECEPTORS AND USES THEREOF | BIONOMICS LIMITED (AU) | 2021-07-29 | — | — | US | disclosed |
| WO-2019218025-A1 | MODULATORS OF ION CHANNEL RECEPTORS AND USES THEREOF | BIONOMICS LIMITED (AU) | 2019-11-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210230165-A1 | MODULATORS OF ION CHANNEL RECEPTORS AND USES THEREOF | TRPV1, TRPM8, TRPV2 | TP53 4752/4885LMNA 2920/4885PARP15 2847/4885 |
| US-11384085-B2 | Modulators of ion channel receptors and uses thereof | TRPV1, TRPM8, TRPV2 | TP53 4752/4885LMNA 2920/4885PARP15 2847/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.