Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 14/20 | 0.67 |
| ▸ | ERG | P11308 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.44 |
| ▸ | CCR5 | P51681 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1830874 | 0.86 | SMO (0.74) | SMOERG | |
| SCHEMBL1653518 | 0.82 | TUBB4A (0.60) | GAATHRBSMN1; SMN2GPR119 | |
| SCHEMBL8146112 | 0.81 | HCRTR1 (0.50) | SMOGAATHRBSMN1; SMN2GPR119 | |
| SCHEMBL29891783 | 0.81 | HCRTR1 (0.50) | SMOGAATHRBSMN1; SMN2GPR119 | |
| SCHEMBL2901393 | 0.80 | TUBB4A (0.58) | GAATHRBSMN1; SMN2GPR119 | |
| SCHEMBL3779989 | 0.80 | HTR2B (0.61) | GAATHRBSMN1; SMN2GPR119OPRM1 | |
| SCHEMBL1831382 | 0.79 | PDE10A (0.53) | SMOGAATHRBSMN1; SMN2GPR119 | |
| SCHEMBL4423384 | 0.79 | GPR119 (0.59) | SMN1; SMN2GPR119 | |
| SCHEMBL12580552 | 0.79 | ALDH1A1 (0.63) | SMOERGGAATHRBSMN1; SMN2 | |
| SCHEMBL12580530 | 0.79 | EPHX2 (0.64) | SMOGAASMN1; SMN2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110183974-A1 | 1,2,4-OXADIAZOLE SUBSTITUTED PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS | INSTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI (IT) | 2011-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110183974-A1 | 1,2,4-OXADIAZOLE SUBSTITUTED PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS | SHH, SMO, GLI1 | SMO 2/4885ERG 2205/4885GAA 4330/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.