Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | THPO | P40225 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10723225 | 0.90 | KDM4E (0.64) | KDM4EALDH1A1CYP1A2POLBCYP3A4 | |
| SCHEMBL10723235 | 0.90 | KDM4E (0.64) | KDM4EALDH1A1CYP1A2POLBCYP3A4 | |
| SCHEMBL17580480 | 0.86 | CA2 (0.50) | KDM4EALDH1A1CYP1A2POLBCYP3A4 | |
| SCHEMBL7270148 | 0.84 | KDM4E (0.48) | KDM4EALDH1A1CYP1A2POLBCYP3A4 | |
| SCHEMBL6718744 | 0.84 | ALDH1A1 (0.56) | KDM4EALDH1A1CYP1A2POLBCYP3A4 | |
| SCHEMBL2573120 | 0.82 | BLM (0.50) | KDM4EALDH1A1CYP1A2POLBCYP3A4 | |
| SCHEMBL2982712 | 0.82 | BLM (0.50) | KDM4EALDH1A1CYP1A2POLBCYP3A4 | |
| SCHEMBL6107394 | 0.80 | KDM4E (0.43) | KDM4EALDH1A1CYP1A2POLBCYP3A4 | |
| SCHEMBL6107393 | 0.80 | KDM4E (0.43) | KDM4EALDH1A1CYP1A2POLBCYP3A4 | |
| SCHEMBL8939569 | 0.80 | CTSB (0.54) | KDM4EALDH1A1CYP1A2POLBCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210355166-A1 | ANALGESICS AND METHODS OF USE THEREOF | UNIV SYDNEY (AU) | 2021-11-18 | — | — | US | disclosed |
| EP-3802560-A1 | ANALGESICS AND METHODS OF USE THEREOF | The University of Sydney (AU) | 2021-04-14 | — | — | EP | disclosed |
| CN-112469729-A | Analgesic and method of use | 悉尼大学 | 2021-03-09 | — | — | CN | disclosed |
| WO-2019227163-A1 | ANALGESICS AND METHODS OF USE THEREOF | THE UNIVERSITY OF SYDNEY (AU) | 2019-12-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210355166-A1 | ANALGESICS AND METHODS OF USE THEREOF | OPRL1, OPRD1, VIP | KDM4E 4479/4885ALDH1A1 699/4885CYP1A2 1283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.