Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28435272 | 0.79 | ALDH1A1 (0.39) | SMN1; SMN2RAB9AALDH1A1LMNAMAPT | |
| SCHEMBL21291535 | 0.76 | CHEK1 (0.39) | SMN1; SMN2ALDH1A1LMNATHRBTSHR | |
| SCHEMBL28394145 | 0.75 | DGAT1 (0.35) | LMNAKMT2A | |
| SCHEMBL5813872 | 0.72 | PDE4A (0.41) | SMN1; SMN2RAB9AALDH1A1LMNAMAPT | |
| SCHEMBL20528938 | 0.72 | KMT2A (0.40) | SMN1; SMN2RAB9AALDH1A1LMNAMAPT | |
| SCHEMBL4388002 | 0.72 | MAPK1 (0.34) | ALDH1A1LMNATHRBTSHRMAPK1 | |
| SCHEMBL18717726 | 0.70 | — | — | |
| SCHEMBL21582005 | 0.69 | ADORA2A (0.36) | MAPT | |
| SCHEMBL19098523 | 0.67 | ALDH1A1 (0.36) | SMN1; SMN2RAB9AALDH1A1LMNATHRB | |
| SCHEMBL30625835 | 0.67 | SMN1; SMN2 (0.40) | SMN1; SMN2ALDH1A1LMNATHRBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3728257-A1 | AUTOTAXIN INHIBITORS AND USES THEREOF | Fronthera U.S. Pharmaceuticals LLC (US) | 2020-10-28 | — | — | EP | disclosed |
| WO-2019228403-A1 | AUTOTAXIN INHIBITORS AND USES THEREOF | FRONTHERA U.S. PHARMACEUTICALS LLC (US) | 2019-12-05 | — | — | WO | disclosed |