Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 5/20 | 0.56 |
| ▸ | MAOA | P21397 | 2/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | CDK4 | P11802 | 1/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.48 |
| ▸ | CCND1 | P24385 | 1/20 | 0.48 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.48 |
| ▸ | TOP1 | P11387 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 2/20 | 0.46 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.46 |
| ▸ | ERN1 | O75460 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29475632 | 1.00 | MAOB (0.56) | MAOBMAOAALOX5CCNB2CDK1 | |
| SCHEMBL6246117 | 0.88 | MAOB (0.56) | MAOBMAOAALOX5CCNB2CDK1 | |
| SCHEMBL8327914 | 0.85 | MAOA (0.61) | MAOBMAOAALOX5CCNB2CDK1 | |
| SCHEMBL3615463 | 0.83 | MAOB (0.58) | MAOBMAOAALOX5CCNB2CDK1 | |
| SCHEMBL7426013 | 0.81 | MAOB (0.56) | MAOBMAOAALOX5CCNB2CDK1 | |
| SCHEMBL1588758 | 0.81 | BACE1 (0.57) | MAOBMAOAALOX5CCNB2CDK1 | |
| SCHEMBL20767540 | 0.81 | MAOB (0.56) | MAOBMAOAALOX5CCNB2CDK1 | |
| SCHEMBL3621341 | 0.81 | MAOB (0.56) | MAOBMAOAALOX5ERN1LMNA | |
| SCHEMBL16319302 | 0.81 | MAOB (0.56) | MAOBMAOAALOX5CCNB2CDK1 | |
| SCHEMBL29901179 | 0.81 | MAOB (0.56) | MAOBMAOAALOX5ERN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11583507-B2 | Direct AMPK activator compounds | SOCIETE DES PRODUITS NESTLE S.A. (CH) | 2023-02-21 | — | — | US | disclosed |
| US-11583507-B2 | Direct AMPK activator compounds | SOCIETE DES PRODUITS NESTLE S.A. (CH) | 2023-02-21 | — | — | US | disclosed |
| EP-3968976-A1 | PHENANTHRENE AMPK ACTIVATOR COMPOUNDS, COMPOSITIONS, METHODS AND USES THEREOF | Société des Produits Nestlé S.A. (CH) | 2022-03-23 | — | — | EP | disclosed |
| US-20220062199-A1 | PHENANTHRENE AMPK ACTIVATOR COMPOUNDS, COMPOSITIONS, METHODS AND USES THEREOF | NESTLE SA (CH) | 2022-03-03 | — | — | US | disclosed |
| CN-113784708-A | Phenanthrene AMPK activator compounds, compositions, methods, and uses thereof | 雀巢产品有限公司 | 2021-12-10 | — | — | CN | disclosed |
| EP-3801475-A1 | DIRECT AMPK ACTIVATOR COMPOUNDS | Société des Produits Nestlé S.A. (CH) | 2021-04-14 | — | — | EP | disclosed |
| US-20210038536-A1 | DIRECT AMPK ACTIVATOR COMPOUNDS | SOCIETE DES PRODUITS NESTLE S.A. (CH) | 2021-02-11 | — | — | US | disclosed |
| US-20210038536-A1 | DIRECT AMPK ACTIVATOR COMPOUNDS | SOCIETE DES PRODUITS NESTLE S.A. (CH) | 2021-02-11 | — | — | US | disclosed |
| CN-112203647-A | Direct AMPK activator compounds | 雀巢产品有限公司 | 2021-01-08 | — | — | CN | disclosed |
| WO-2020229375-A1 | PHENANTHRENE AMPK ACTIVATOR COMPOUNDS, COMPOSITIONS, METHODS AND USES THEREOF | Société des Produits Nestlé S.A. (CH) | 2020-11-19 | — | — | WO | disclosed |
| WO-2020229375-A1 | PHENANTHRENE AMPK ACTIVATOR COMPOUNDS, COMPOSITIONS, METHODS AND USES THEREOF | Société des Produits Nestlé S.A. (CH) | 2020-11-19 | — | — | WO | disclosed |
| WO-2019228794-A1 | DIRECT AMPK ACTIVATOR COMPOUNDS | SOCIETE DES PRODUITS NESTLE S.A. (CH) | 2019-12-05 | — | — | WO | disclosed |
| WO-2019228794-A1 | DIRECT AMPK ACTIVATOR COMPOUNDS | SOCIETE DES PRODUITS NESTLE S.A. (CH) | 2019-12-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11583507-B2 | Direct AMPK activator compounds | PRKAG2, AK2, PRKAG3 | MAOB 3811/4885MAOA 3259/4885ALOX5 1849/4885 |
| US-20210038536-A1 | DIRECT AMPK ACTIVATOR COMPOUNDS | PRKAG2, AK2, PRKAG3 | MAOB 3811/4885MAOA 3259/4885ALOX5 1849/4885 |
| US-20220062199-A1 | PHENANTHRENE AMPK ACTIVATOR COMPOUNDS, COMPOSITIONS, METHODS AND USES THEREOF | PRKAG2, PRKAG1, PRKAG3 | MAOB 3790/4885MAOA 2753/4885ALOX5 3491/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.