Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MC4R | P32245 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | MC3R | P41968 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.50 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrazine Carboxylic Acid Hydrazide SCHEMBL107341 | 0.77 | ADORA3 (0.61) | ADORA3TSHRMC4RADRA1AMC3R | |
| SCHEMBL8336840 | 0.77 | KDM4E (0.63) | ADORA3TSHRMC4RADRA1AMC3R | |
| Pyrazine Carboxylic Acid Hydrazide SCHEMBL18038330 | 0.76 | ADORA3 (0.59) | ADORA3TSHRMC4RADRA1AMC3R | |
| SCHEMBL21585663 | 0.75 | CES2 (0.52) | KDM4ENAPRTHDAC3HDAC1HDAC2 | |
| Hydrochloric Acid SCHEMBL27752878 | 0.74 | KDM4E (0.48) | ADORA3TSHRMC4RADRA1AMC3R | |
| SCHEMBL27791569 | 0.72 | KDM4E (0.55) | ADORA3TSHRMC4RADRA1AMC3R | |
| SCHEMBL5796700 | 0.71 | KDM4E (0.50) | ADORA3TSHRMC4RADRA1AMC3R | |
| SCHEMBL4904135 | 0.71 | BAZ2B (0.52) | ADORA3TSHRMC4RADRA1AMC3R | |
| Pyrazinamide SCHEMBL18364989 | 0.70 | — | — | |
| Pyrazinamide SCHEMBL24102 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4178563-A1 | TYROSINE, TRYPTOPHAN AND PHENYLALANINE AS MTOR AGONISTS MEDIATING PROTEASOME DYNAMICS, COMPOSITIONS, METHODS AND USES THEREOF IN THERAPY, AND PROGNOSTIC METHODS FOR DRUG-RESISTANCE | Technion Research & Development Foundation Ltd. (IL) | 2023-05-17 | — | — | EP | disclosed |
| EP-3802501-A1 | COMPOUNDS AS NUCLEAR TRANSPORT MODULATORS AND USES THEREOF | XW Laboratories Inc. (KY) | 2021-04-14 | — | — | EP | disclosed |
| WO-2019233447-A1 | COMPOUNDS AS NUCLEAR TRANSPORT MODULATORS AND USES THEREOF | XW LABORATORIES, INC. (CN) | 2019-12-12 | — | — | WO | disclosed |