Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 3/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | TYK2 | P29597 | 1/20 | 0.57 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.52 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.52 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.52 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1437928 | 0.88 | KMT2A (0.80) | LMNAKMT2AMEN1HPGDTYK2 | |
| SCHEMBL4138460 | 0.88 | POLB (0.67) | LCKLMNAKMT2AMEN1POLB | |
| SCHEMBL21590301 | 0.86 | MEN1 (0.55) | LCKLMNAKMT2AMEN1TYK2 | |
| SCHEMBL11402399 | 0.84 | PDK1 (0.59) | LCKKMT2APOLBCHRNA7MAPK14 | |
| SCHEMBL28510576 | 0.83 | LCK (0.61) | LCKLMNAKMT2AMEN1TYK2 | |
| SCHEMBL7827455 | 0.83 | POLB (0.79) | LCKKMT2AMEN1POLBCHRNA7 | |
| SCHEMBL773400 | 0.83 | LCK (1.00) | LCKLMNACHRNA7MAPT | |
| SCHEMBL773593 | 0.83 | LCK (1.00) | LCKMAPK14 | |
| SCHEMBL3785470 | 0.81 | LMNA (0.66) | LMNAKMT2AMEN1POLBHPGD | |
| SCHEMBL18610497 | 0.81 | RORC (0.63) | LCKLMNAKMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111635404-B | Preparation method of duloxetine | 苏州明锐医药科技有限公司 | 2023-11-07 | — | — | CN | claimed |
| CN-111675710-B | Preparation method of duloxetine | 上海奥萝拉医药科技有限公司 | 2023-08-18 | — | — | CN | claimed |
| CN-111675710-A | Preparation method of dovinisine | 苏州明锐医药科技有限公司 | 2020-09-18 | — | — | CN | claimed |
| CN-111635404-A | Preparation method of dovinisine | 苏州明锐医药科技有限公司 | 2020-09-08 | — | — | CN | claimed |
| CN-118388485-B | Du Weili Sibub synthesis method | 江苏海洋大学 | 2024-11-05 | — | — | CN | disclosed |
| CN-118388485-A | Du Weili Sibub synthesis method | 江苏海洋大学 | 2024-07-26 | — | — | CN | disclosed |
| CN-118324765-A | Synthesis method of PI3K inhibitor Du Weili sibutra | 江苏海洋大学 | 2024-07-12 | — | — | CN | disclosed |
| CN-111635404-B | Preparation method of duloxetine | 苏州明锐医药科技有限公司 | 2023-11-07 | — | — | CN | disclosed |
| CN-111675710-B | Preparation method of duloxetine | 上海奥萝拉医药科技有限公司 | 2023-08-18 | — | — | CN | disclosed |
| CN-111675710-A | Preparation method of dovinisine | 苏州明锐医药科技有限公司 | 2020-09-18 | — | — | CN | disclosed |
| CN-111635404-A | Preparation method of dovinisine | 苏州明锐医药科技有限公司 | 2020-09-08 | — | — | CN | disclosed |
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |
| CN-109071462-A | Quinazoline derivative or salt thereof and pharmaceutical composition containing the same | 柳韩洋行 | 2018-12-21 | — | — | CN | disclosed |
| CN-104447727-B | Substituted amino-metadiazine compound and its application method and purposes | 广东东阳光药业有限公司 | 2018-04-27 | — | — | CN | disclosed |
| CN-107690433-A | Heteroaryl derivative or its pharmaceutically acceptable salt, its preparation method and include the pharmaceutical composition for being used to prevent or treat PI3 kinase-associated conditions ited as active component | 韩国化学研究院 | 2018-02-13 | — | — | CN | disclosed |
| CN-104447727-A | Substituted aminopyrimidine compound as well as use method and application thereof | GUANGDONG HEC PHARMACEUTICAL | 2015-03-25 | — | — | CN | disclosed |