SCHEMBL2159077

SCHEMBL2159077

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nearest known ligand 0.36

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
PAX8 Q06710 1/20 0.36
USP2 O75604 1/20 0.34
SLCO1B1 Q9Y6L6 1/20 0.34
PTGS1 P23219 1/20 0.32
SLC7A11 Q9UPY5 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1788963 0.82 PAX8 (0.41) PAX8USP2SLCO1B1
SCHEMBL17767377 0.82 PAX8 (0.41) PAX8USP2SLCO1B1
SCHEMBL736616 0.81 USP2 (0.39) PAX8USP2SLCO1B1PTGS1SLC7A11
SCHEMBL2159143 0.80 PAX8 (0.34) PAX8
SCHEMBL8038751 0.80 PAX8 (0.39) PAX8
SCHEMBL9807660 0.80 USP2 (0.43) PAX8USP2SLCO1B1
SCHEMBL9807657 0.80 USP2 (0.43) PAX8USP2SLCO1B1
SCHEMBL9617278 0.78 PAX8 (0.40) PAX8USP2SLCO1B1
SCHEMBL2223103 0.78 PAX8 (0.40) PAX8USP2SLCO1B1
SCHEMBL16429713 0.78 USP2 (0.38) PAX8USP2SLCO1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150023941-A1 Compositions Comprising Sugar-Cysteine Products EAST WEST BANK 2015-01-22 US disclosed
US-20140348811-A1 COMPOSITIONS COMPRISING SUGAR-CYSTEINE PRODUCTS MAX INTERNATIONAL, LLC (US) 2014-11-27 US disclosed
US-8853170-B2 Compositions comprising sugar-cysteine products MAX INTERNATIONAL, LLC (US) 2014-10-07 US disclosed
WO-2013016636-A1 COMPOSITIONS COMPRISING SUGAR-CYSTEINE PRODUCTS MAX INTERNATIONAL, LLC (US) 2013-01-31 WO disclosed
WO-2011149835-A1 COMPOSITIONS AND BEVERAGES COMPRISING NUTRIENTS, VITAMINS, SUGARS, CYSTEINE, AND/OR SUGAR-CYSTEINE PRODUCTS MAX INTERNATIONAL, LLC (US) 2011-12-01 WO disclosed
US-20110287109-A1 Compositions And Beverages Comprising Nutrients, Vitamins, Sugars, Cysteine, And/Or Sugar-Cysteine Products MAX INTERNATIONAL, LLC (US) 2011-11-24 US disclosed
WO-2011094491-A1 COMPOSITIONS COMPRISING SUGAR-CYSTEINE PRODUCTS MAX INTERNATIONAL, LLC (US) 2011-08-04 WO disclosed
WO-2011094490-A1 METHODS OF PREPARING THIAZOLIDINES MAX INTERNATIONAL, LLC (US) 2011-08-04 WO disclosed
US-20110183927-A1 Compositions Comprising Sugar-Cysteine Products MAX INTERNATIONAL, LLC (US) 2011-07-28 US disclosed
US-20110184185-A1 Methods Of Preparing Thiazolidines MAX INTERNATIONAL, LLC (US) 2011-07-28 US disclosed
WO-2010133975-A2 REDUCIBLE POLYAMINO DISULFIDES AS TRANSFECTANTS IMUTHES LIMITED (GB) 2010-11-25 WO disclosed
US-20080200563-A1 Use of Compounds Containing Thiol Groups as Efflux Pump Inhibitors THIOMATRIX FORSCHUNGS- UND BERATUNGS- GMBH (AT) 2008-08-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110184185-A1 Methods Of Preparing Thiazolidines RPIA, DPYD, TXN PAX8 2269/4885USP2 2626/4885SLCO1B1 734/4885
US-20150023941-A1 Compositions Comprising Sugar-Cysteine Products CBS, CTH, GCLC PAX8 3570/4885USP2 586/4885SLCO1B1 455/4885
US-20140348811-A1 COMPOSITIONS COMPRISING SUGAR-CYSTEINE PRODUCTS CBS, CTH, GCLC PAX8 3570/4885USP2 586/4885SLCO1B1 455/4885
US-20110183927-A1 Compositions Comprising Sugar-Cysteine Products CBS, CTH, GCLC PAX8 3570/4885USP2 586/4885SLCO1B1 455/4885
US-20110287109-A1 Compositions And Beverages Comprising Nutrients, Vitamins, Sugars, Cysteine, And/Or Sugar-Cysteine Products CBS, PROC, SLC7A11 PAX8 3426/4885USP2 2067/4885SLCO1B1 255/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.