Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30694895 | 0.86 | SLC6A4 (0.57) | SLC6A4SLC6A2SLC6A3 | |
| Trifluoroacetic Acid SCHEMBL21590734 | 0.81 | — | — | |
| Trifluoroacetic Acid SCHEMBL23830840 | 0.78 | SLC6A2 (0.47) | SLC6A4SLC6A2SLC6A3 | |
| Trifluoroacetic Acid SCHEMBL21723079 | 0.77 | SLC6A4 (0.55) | SLC6A4SLC6A2SLC6A3 | |
| Trifluoroacetic Acid SCHEMBL23830800 | 0.76 | SLC6A2 (0.45) | SLC6A4SLC6A2SLC6A3 | |
| Trifluoroacetic Acid SCHEMBL30619319 | 0.75 | TACR1 (0.41) | SLC6A4LNPEP | |
| Trifluoroacetic Acid SCHEMBL23830644 | 0.75 | SLC6A4 (0.48) | SLC6A4SLC6A2SLC6A3 | |
| Trifluoroacetic Acid SCHEMBL23831006 | 0.75 | GRIN1 (0.43) | — | |
| Trifluoroacetic Acid SCHEMBL21590609 | 0.75 | SLC6A2 (0.49) | SLC6A4SLC6A2SLC6A3 | |
| Trifluoroacetic Acid SCHEMBL28921589 | 0.75 | SLC6A4 (0.48) | SLC6A4SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11840528-B2 | Isoxazolyl ether derivatives as GABAA α5 PAM | HOFFMANN-LA ROCHE INC. (US) | 2023-12-12 | — | — | US | disclosed |
| EP-3807269-A1 | NEW ISOXAZOLYL ETHER DERIVATIVES AS GABA A ALPHA5 PAM | F. Hoffmann-La Roche AG (CH) | 2021-04-21 | — | — | EP | disclosed |
| US-20210094945-A1 | NEW ISOXAZOLYL ETHER DERIVATIVES AS GABA A ALPHA5 PAM | HOFFMANN-LA ROCHE INC. (US) | 2021-04-01 | — | — | US | disclosed |
| WO-2019238633-A1 | NEW ISOXAZOLYL ETHER DERIVATIVES AS GABA A ALPHA5 PAM | F. HOFFMANN-LA ROCHE AG (CH) | 2019-12-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11840528-B2 | Isoxazolyl ether derivatives as GABAA α5 PAM | GABRA5, GABRA2, GABRB2 | SLC6A4 729/4885SLC6A2 1136/4885SLC6A3 710/4885 |
| US-20210094945-A1 | NEW ISOXAZOLYL ETHER DERIVATIVES AS GABA A ALPHA5 PAM | GABRA5, GABRB2, GABRB1 | SLC6A4 867/4885SLC6A2 1814/4885SLC6A3 827/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.