Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 3/20 | 0.41 |
| ▸ | NOS3 | P29474 | 2/20 | 0.41 |
| ▸ | NOS1 | P29475 | 2/20 | 0.41 |
| ▸ | NOS2 | P35228 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 4/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.40 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | TKT | P29401 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27857868 | 0.91 | RAB9A (0.43) | KDM1AMAOAMAOBBACE1NOS3 | |
| SCHEMBL14698505 | 0.88 | GBA1 (0.46) | KDM1AMAOAMAOBBACE1HTR1A | |
| SCHEMBL12466143 | 0.88 | KDM1A (0.40) | KDM1AMAOAMAOBBACE1NOS3 | |
| Hydrochloric Acid SCHEMBL29086107 | 0.82 | KDM1A (0.40) | KDM1AMAOAMAOBBACE1NOS3 | |
| SCHEMBL18228047 | 0.81 | JAK2 (0.46) | ALOX5APFEN1 | |
| SCHEMBL7861456 | 0.79 | KDM1A (0.34) | KDM1AMAOAMAOBHTR1AADRA2A | |
| SCHEMBL928160 | 0.77 | NOS2 (0.41) | BACE1NOS3NOS1NOS2HTR1A | |
| SCHEMBL32691181 | 0.77 | CYP11B1 (0.44) | HTR1AADRA2AADRA2BADRA2CNPC1 | |
| SCHEMBL8668529 | 0.77 | HTR1A (0.40) | HTR1AADRA2AADRA2BADRA2CNPC1 | |
| SCHEMBL27752556 | 0.77 | KDM1A (0.41) | KDM1AMAOAMAOBBACE1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3807273-A1 | AZAINDOLE DERIVATIVES AS RHO- KINASE INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2021-04-21 | — | — | EP | claimed |
| WO-2019238628-A1 | AZAINDOLE DERIVATIVES AS RHO- KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2019-12-19 | — | — | WO | claimed |