Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 19/20 | 0.33 |
| ▸ | DNER | Q8NFT8 | 2/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | TSPO | P30536 | 1/20 | 0.32 |
| ▸ | BRD2 | P25440 | 4/20 | 0.31 |
| ▸ | BRD3 | Q15059 | 4/20 | 0.31 |
| ▸ | BRDT | Q58F21 | 4/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | BRD1 | O95696 | 1/20 | 0.31 |
| ▸ | CCL2 | P13500 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | EP300 | Q09472 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.31 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21914871 | 0.85 | BRD4 (0.36) | BRD4DNERADORA3TSPOBRD2 | |
| SCHEMBL21591798 | 0.77 | TSHR (0.39) | BRD4DNERADORA3TSPOBRD2 | |
| SCHEMBL21591797 | 0.69 | BRD4 (0.34) | BRD4DNERADORA3TSPOBRD2 | |
| SCHEMBL21594280 | 0.68 | BRD4 (0.53) | BRD4DNERADORA3TSPOBRD2 | |
| SCHEMBL21915465 | 0.67 | ALDH1A1 (0.37) | BRD4 | |
| SCHEMBL21847307 | 0.67 | P2RX7 (0.43) | BRD4 | |
| SCHEMBL25882842 | 0.67 | BRD4 (0.45) | BRD4DNERADORA3TSPOBRD2 | |
| SCHEMBL21847266 | 0.65 | RAB9A (0.39) | — | |
| SCHEMBL28529850 | 0.64 | TSHR (0.39) | BRD4DNERADORA3TSPOBRD2 | |
| SCHEMBL8320823 | 0.63 | HTT (0.33) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11708374-B2 | Preparation of condensed triazepine derivatives and their use as BET inhibitors | Worg Pharmaceuticals (Zhejiang) Co., Ltd. (CN) | 2023-07-25 | — | — | US | disclosed |
| US-11708374-B2 | Preparation of condensed triazepine derivatives and their use as BET inhibitors | Worg Pharmaceuticals (Zhejiang) Co., Ltd. (CN) | 2023-07-25 | — | — | US | disclosed |
| US-11708374-B2 | Preparation of condensed triazepine derivatives and their use as BET inhibitors | Worg Pharmaceuticals (Zhejiang) Co., Ltd. (CN) | 2023-07-25 | — | — | US | disclosed |
| EP-3806860-A1 | PREPARATION OF CONDENSED TRIAZEPINE DERIVATIVES AND THEIR USE AS BET INHIBITORS | Dybly AG (CH) | 2021-04-21 | — | — | EP | disclosed |
| US-20210101909-A1 | PREPARATION OF CONDENSED TRIAZEPINE DERIVATIVES AND THEIR USE AS BET INHIBITORS | Worg Pharmaceuticals (Zhejiang) Co., Ltd. (CN) | 2021-04-08 | — | — | US | disclosed |
| US-20210101909-A1 | PREPARATION OF CONDENSED TRIAZEPINE DERIVATIVES AND THEIR USE AS BET INHIBITORS | Worg Pharmaceuticals (Zhejiang) Co., Ltd. (CN) | 2021-04-08 | — | — | US | disclosed |
| US-10906917-B2 | Preparation of condensed triazepine derivatives and their use as BET inhibitors | DYBLY AG (CH) | 2021-02-02 | — | — | US | disclosed |
| US-10906917-B2 | Preparation of condensed triazepine derivatives and their use as BET inhibitors | DYBLY AG (CH) | 2021-02-02 | — | — | US | disclosed |
| US-20200231598-A1 | PREPARATION OF CONDENSED TRIAZEPINE DERIVATIVES AND THEIR USE AS BET INHIBITORS | Worg Pharmaceuticals (Zhejiang) Co., Ltd. (CN) | 2020-07-23 | — | — | US | disclosed |
| US-20200231598-A1 | PREPARATION OF CONDENSED TRIAZEPINE DERIVATIVES AND THEIR USE AS BET INHIBITORS | Worg Pharmaceuticals (Zhejiang) Co., Ltd. (CN) | 2020-07-23 | — | — | US | disclosed |
| WO-2019238557-A1 | PREPARATION OF CONDENSED TRIAZEPINE DERIVATIVES AND THEIR USE AS BET INHIBITORS | DYBLY AG (CH) | 2019-12-19 | — | — | WO | disclosed |
| WO-2019238557-A1 | PREPARATION OF CONDENSED TRIAZEPINE DERIVATIVES AND THEIR USE AS BET INHIBITORS | DYBLY AG (CH) | 2019-12-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11708374-B2 | Preparation of condensed triazepine derivatives and their use as BET inhibitors | BET1, EP300, BICRA | BRD4 4/4885DNER 1399/4885ADORA3 4536/4885 |
| US-20210101909-A1 | PREPARATION OF CONDENSED TRIAZEPINE DERIVATIVES AND THEIR USE AS BET INHIBITORS | BET1, EP300, BICRA | BRD4 4/4885DNER 1399/4885ADORA3 4536/4885 |
| US-10906917-B2 | Preparation of condensed triazepine derivatives and their use as BET inhibitors | BET1, EP300, BICRA | BRD4 4/4885DNER 1399/4885ADORA3 4536/4885 |
| US-20200231598-A1 | PREPARATION OF CONDENSED TRIAZEPINE DERIVATIVES AND THEIR USE AS BET INHIBITORS | BET1, EP300, BICRA | BRD4 4/4885DNER 1399/4885ADORA3 4536/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.