Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.58 |
| ▸ | CES1 | P23141 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | NOS2 | P35228 | 2/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL216550 | 1.00 | CES2 (0.58) | CES2CES1KDM4EMAPTKMT2A | |
| SCHEMBL28636550 | 1.00 | CES2 (0.58) | CES2CES1KDM4EMAPTKMT2A | |
| SCHEMBL30542351 | 1.00 | CES2 (0.58) | CES2CES1KDM4EMAPTKMT2A | |
| SCHEMBL30542352 | 1.00 | CES2 (0.58) | CES2CES1KDM4EMAPTKMT2A | |
| SCHEMBL217106 | 1.00 | CES2 (0.58) | CES2CES1KDM4EMAPTKMT2A | |
| SCHEMBL25485911 | 1.00 | CES2 (0.58) | CES2CES1KDM4EMAPTKMT2A | |
| SCHEMBL217428 | 1.00 | CES2 (0.58) | CES2CES1KDM4EMAPTKMT2A | |
| Cyclohexane Carboxamide SCHEMBL26181 | 1.00 | — | — | |
| SCHEMBL218387 | 1.00 | CES2 (0.58) | CES2CES1KDM4EMAPTKMT2A | |
| SCHEMBL27938035 | 1.00 | CES2 (0.58) | CES2CES1KDM4EMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 364 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240025884-A1 | COMPOUNDS AS GCN2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | DONG-A ST CO., LTD. (KR) | 2024-01-25 | — | — | US | claimed |
| CN-112578059-A | Detection method of fluoxetine and norfluoxetine | 北京和合医学诊断技术股份有限公司 | 2021-03-30 | — | — | CN | claimed |
| CN-112034078-A | Method for detecting carbamazepine | 北京和合医学诊断技术股份有限公司 | 2020-12-04 | — | — | CN | claimed |
| US-8916599-B2 | 1H-benz imidazole-5-carboxamides as anti-inflammatory agents | OREXO AB (SE) | 2014-12-23 | — | — | US | claimed |
| EP-1498411-B9 | DIKETOHYDRAZINE DERIVATIVE COMPOUNDS AND DRUGS CONTAINING THE COMPOUNDS AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO (JP) | 2013-12-04 | — | — | EP | claimed |
| EP-1945206-B1 | INDOLE DERIVATIVES AS HISTAMINE 3 RECEPTOR INHIBITORS FOR THE TREATMENT OF COGNITIVE AND SLEEP DISORDERS, OBESITY AND OTHER CNS DISORDERS | ATHERSYS INC (US) | 2013-04-24 | — | — | EP | claimed |
| EP-1498411-B1 | DIKETOHYDRAZINE DERIVATIVE COMPOUNDS AND DRUGS CONTAINING THE COMPOUNDS AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO (JP) | 2013-01-16 | — | — | EP | claimed |
| US-20110312935-A1 | 1H-Benz Imidazole-5-Carboxamides As Anti-Inflammatory Agents | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-12-22 | — | — | US | claimed |
| EP-1928840-B1 | 1H-Pyrazole-4-carboxamides, their preparation and their use as 11-beta-hydroxysteroid dehydrogenase inhibitors | HOFFMANN LA ROCHE (CH) | 2011-08-10 | — | — | EP | claimed |
| US-7838529-B2 | Xanthine derivates, their preparation and their use in pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-11-23 | — | — | US | claimed |
| US-20030235543-A1 | Topical administration of pharmacologically active bases for skin lightening | MAIBACH HOWARD I (US) | 2003-12-25 | — | — | US | claimed |
| US-20030235627-A1 | Topical administration of pharmacologically active bases in the treatment of warts | TECHNOLOGY RECOVERY SYSTEMS, LLC | 2003-12-25 | — | — | US | claimed |
| US-20030099678-A1 | Method and topical formulation for treating skin conditions associated with aging | TECHNOLOGY RECOVERY SYSTEMS, LLC | 2003-05-29 | — | — | US | claimed |
| US-20030077301-A1 | Topical pharmaceutical composition for the treatment of inflammatory dermatoses | DERMATRENDS, INC. | 2003-04-24 | — | — | US | claimed |
| US-20030072814-A1 | Topical pharmaceutical composition for the treatment of warts | DERMATRENDS, INC. | 2003-04-17 | — | — | US | claimed |
| US-20030072724-A1 | Topical pharmaceutical composition to treat hyperpigmentation of the skin | MAIBACH HOWARD I (US) | 2003-04-17 | — | — | US | claimed |
| WO-2003026680-A2 | METHOD AND TOPICAL FORMULATION FOR TREATING SKIN CONDITIONS ASSOCIATED WITH AGING | DERMATRENDS, INC. (US) | 2003-04-03 | — | — | WO | claimed |
| US-20030059450-A1 | Method and topical formulation for treating skin conditions associated with aging | MAIBACH HOWARD I (US) | 2003-03-27 | — | — | US | claimed |
| EP-1294707-A2 | THIOPHENE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2003-03-26 | — | — | EP | claimed |
| WO-2001098290-A2 | THIOPHENE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA S.P.A. (IT) | 2001-12-27 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110312935-A1 | 1H-Benz Imidazole-5-Carboxamides As Anti-Inflammatory Agents | MAPRE2, MAPRE1, H1-4 | CES2 3637/4885CES1 2526/4885KDM4E 140/4885 |
| US-20240025884-A1 | COMPOUNDS AS GCN2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | EIF2AK4, GCN1, GCGR | CES2 2482/4885CES1 520/4885KDM4E 4591/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.