Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | LTA4H | P09960 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | LSS | P48449 | 2/20 | 0.47 |
| ▸ | FDPS | P14324 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10829125 | 0.95 | LTA4H (0.63) | KDM4ESMN1; SMN2LTA4HMEN1KMT2A | |
| SCHEMBL10877728 | 0.88 | LTA4H (0.69) | KDM4ESMN1; SMN2LTA4HFDPSALDH1A1 | |
| SCHEMBL21595690 | 0.85 | DRD2 (0.60) | KDM4ESMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL2476605 | 0.85 | KDM4E (0.49) | KDM4ESMN1; SMN2LTA4HMEN1KMT2A | |
| SCHEMBL7994823 | 0.84 | LTA4H (0.56) | KDM4ESMN1; SMN2LTA4HMEN1KMT2A | |
| SCHEMBL21595777 | 0.83 | KDM4E (0.48) | KDM4ESMN1; SMN2LTA4HMEN1KMT2A | |
| SCHEMBL21595882 | 0.83 | HRH3 (0.58) | KDM4ESMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL15068015 | 0.83 | ALDH1A1 (0.58) | KDM4ESMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL10828003 | 0.83 | KDM4E (0.53) | KDM4ESMN1; SMN2LTA4H | |
| Hydrochloric Acid SCHEMBL11854289 | 0.83 | LTA4H (0.54) | KDM4ESMN1; SMN2LTA4HMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019244066-A2 | PYRIDIN-3-YL ACETIC ACID DERIVATIVES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | VIIV Healthcare UK (No.5) Limited (GB) | 2019-12-26 | — | — | WO | disclosed |