SCHEMBL21596869

SCHEMBL21596869

COCc1cc2onc(N)c2cc1C

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.38
KDM4E B2RXH2 1/20 0.37
ALDH1A1 P00352 1/20 0.37
GAA P10253 1/20 0.37
HPGD P15428 1/20 0.37
KAT7 O95251 2/20 0.33
KAT6A Q92794 2/20 0.33
KCNA2 P16389 1/20 0.33
KCNA1 Q09470 1/20 0.33
KAT6B Q8WYB5 1/20 0.33
KAT5 Q92993 1/20 0.33
KAT8 Q9H7Z6 1/20 0.33
ESR1 P03372 2/20 0.32
ESR2 Q92731 2/20 0.32
IDO1 P14902 1/20 0.32
MAPK14 Q16539 1/20 0.31
HSD17B3 P37058 1/20 0.31
CHEK1 O14757 1/20 0.30
MAP4K4 O95819 1/20 0.30
ABL1 P00519 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16060035 0.76 SCN9A (0.53) KDM4EALDH1A1GAAHPGD
SCHEMBL21596945 0.75 LMNA (0.35) LMNAKDM4EALDH1A1GAAHPGD
SCHEMBL21596776 0.73 LMNA (0.40) LMNAKAT7KAT6AKAT6BKAT5
SCHEMBL13414103 0.71 IDO1 (0.36) ESR1ESR2IDO1MAPK14CHEK1
SCHEMBL21596873 0.71 IDO1 (0.40) ESR1ESR2IDO1MAPK14CHEK1
SCHEMBL31432520 0.71 KAT7 (0.56) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL21596905 0.70 MAPK14 (0.44) KDM4EALDH1A1GAAHPGDIDO1
SCHEMBL16059744 0.69 CD44 (0.43) ALDH1A1ESR1ESR2IDO1MAPK14
SCHEMBL11450555 0.69 LTB4R (0.40) LMNAKDM4EALDH1A1GAAHPGD
SCHEMBL26774763 0.69 MAPK14 (0.35) LMNAALDH1A1GAAHPGDESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260062393-A1 Compounds CTXT PTY LTD (AU) 2026-03-05 US disclosed
US-12365655-B2 Compounds CTXT PTY LTD (AU) 2025-07-22 US disclosed
CN-112334466-B Compounds of formula (I) CTXT私人有限公司 2025-05-30 CN disclosed
EP-4335439-A2 COMPOUNDS CTXT PTY LTD (AU) 2024-03-13 EP disclosed
EP-3810602-B1 COMPOUNDS CTXT PTY LTD (AU) 2023-11-01 EP disclosed
EP-3810602-B1 COMPOUNDS CTXT PTY LTD (AU) 2023-11-01 EP disclosed
US-20220153710-A1 Compounds CTXT PTY LTD (AU) 2022-05-19 US disclosed
US-20220153710-A1 Compounds CTXT PTY LTD (AU) 2022-05-19 US disclosed
EP-3810602-A1 COMPOUNDS CTXT Pty Limited (AU) 2021-04-28 EP disclosed
US-20200039945-A1 Compounds CTXT PTY LIMITED (AU) 2020-02-06 US disclosed
US-20200039945-A1 Compounds CTXT PTY LIMITED (AU) 2020-02-06 US disclosed
WO-2019243491-A1 COMPOUNDS CTXT PTY LIMITED (AU) 2019-12-26 WO disclosed
WO-2019243491-A1 COMPOUNDS CTXT PTY LIMITED (AU) 2019-12-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220153710-A1 Compounds SLC10A1, ABCB11, PCSK9 LMNA 1393/4885KDM4E 4009/4885ALDH1A1 981/4885
US-20200039945-A1 Compounds SLC10A1, ABCB11, PCSK9 LMNA 1392/4885KDM4E 4009/4885ALDH1A1 982/4885
US-20260062393-A1 Compounds SCN2B, ABCB11, SCN1B LMNA 3274/4885KDM4E 800/4885ALDH1A1 1864/4885
US-12365655-B2 Compounds SLC10A1, ABCB11, PCSK9 LMNA 1392/4885KDM4E 4009/4885ALDH1A1 982/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.