SCHEMBL21596906

SCHEMBL21596906

COc1cc(-c2ncco2)cc2onc(N)c12

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GLRA3 O75311 1/20 0.36
GLRB P48167 1/20 0.36
MAPT P10636 3/20 0.33
ALDH1A1 P00352 2/20 0.33
NPC1 O15118 1/20 0.33
TTK P33981 1/20 0.33
S1PR1 P21453 3/20 0.33
S1PR3 Q99500 1/20 0.33
DYRK1A Q13627 1/20 0.33
ACLY P53396 1/20 0.32
AURKA O14965 1/20 0.32
ROCK2 O75116 1/20 0.32
RPS6KA5 O75582 1/20 0.32
NTRK1 P04629 1/20 0.32
LCK P06239 1/20 0.32
CSF1R P07333 1/20 0.32
LYN P07948 1/20 0.32
RET P07949 1/20 0.32
KIT P10721 1/20 0.32
FGFR1 P11362 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29652491 0.75 NPC1 (0.48) MAPTALDH1A1NPC1S1PR1TP53
SCHEMBL21596901 0.75 NPC1 (0.48) MAPTALDH1A1NPC1S1PR1TP53
SCHEMBL21596793 0.75 FYN (0.44) MAPTALDH1A1NPC1DYRK1AAURKA
SCHEMBL21609174 0.75 KAT6A (0.63)
SCHEMBL27601818 0.74 ALDH1A1 (0.58) GLRA3GLRBMAPTALDH1A1NPC1
SCHEMBL17055916 0.72 ALDH1A1 (0.58) MAPTALDH1A1TTKS1PR1S1PR3
SCHEMBL21608946 0.71 KAT7 (0.36) MAPTALDH1A1NPC1DYRK1AAURKA
SCHEMBL21596858 0.71 BRD4 (0.41) S1PR1DYRK1ARETKDRLTA4H
SCHEMBL21596867 0.70 KDR (0.56) MAPTALDH1A1DYRK1AAURKAROCK2
SCHEMBL29652439 0.70 KDR (0.56) MAPTALDH1A1DYRK1AAURKAROCK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260062393-A1 Compounds CTXT PTY LTD (AU) 2026-03-05 US disclosed
US-12365655-B2 Compounds CTXT PTY LTD (AU) 2025-07-22 US disclosed
CN-112334466-B Compounds of formula (I) CTXT私人有限公司 2025-05-30 CN disclosed
EP-4335439-A2 COMPOUNDS CTXT PTY LTD (AU) 2024-03-13 EP disclosed
EP-3810602-B1 COMPOUNDS CTXT PTY LTD (AU) 2023-11-01 EP disclosed
EP-3810602-B1 COMPOUNDS CTXT PTY LTD (AU) 2023-11-01 EP disclosed
US-20220153710-A1 Compounds CTXT PTY LTD (AU) 2022-05-19 US disclosed
US-20220153710-A1 Compounds CTXT PTY LTD (AU) 2022-05-19 US disclosed
EP-3810602-A1 COMPOUNDS CTXT Pty Limited (AU) 2021-04-28 EP disclosed
CN-112334466-A Compound (I) CTXT私人有限公司 2021-02-05 CN disclosed
US-20200039945-A1 Compounds CTXT PTY LIMITED (AU) 2020-02-06 US disclosed
US-20200039945-A1 Compounds CTXT PTY LIMITED (AU) 2020-02-06 US disclosed
WO-2019243491-A1 COMPOUNDS CTXT PTY LIMITED (AU) 2019-12-26 WO disclosed
WO-2019243491-A1 COMPOUNDS CTXT PTY LIMITED (AU) 2019-12-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220153710-A1 Compounds SLC10A1, ABCB11, PCSK9 GLRA3 4754/4885GLRB 4180/4885MAPT 1135/4885
US-20200039945-A1 Compounds SLC10A1, ABCB11, PCSK9 GLRA3 4754/4885GLRB 4178/4885MAPT 1136/4885
US-20260062393-A1 Compounds SCN2B, ABCB11, SCN1B GLRA3 504/4885GLRB 418/4885MAPT 2629/4885
US-12365655-B2 Compounds SLC10A1, ABCB11, PCSK9 GLRA3 4754/4885GLRB 4178/4885MAPT 1136/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.