Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.42 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.42 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30723540 | 1.00 | MAPT (0.47) | MAPTPOLBHPGDALDH1A1CYP3A4 | |
| SCHEMBL28150027 | 0.81 | HSPB1 (0.49) | MAPTALDH1A1TDP1TSHRHIF1A | |
| SCHEMBL16953062 | 0.80 | TSHR (0.53) | MAPTALDH1A1TDP1TSHRHSPB1 | |
| SCHEMBL16953059 | 0.80 | TDP1 (0.41) | MAPTPOLBALDH1A1TDP1TSHR | |
| SCHEMBL1610862 | 0.80 | TDP1 (0.41) | MAPTPOLBALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL10532607 | 0.80 | MAPT (0.44) | MAPTPOLBHPGDALDH1A1CYP3A4 | |
| SCHEMBL8989557 | 0.79 | HPGD (0.51) | MAPTPOLBHPGDALDH1A1CYP3A4 | |
| SCHEMBL28024174 | 0.79 | HPGD (0.61) | MAPTPOLBHPGDALDH1A1TDP1 | |
| SCHEMBL6815559 | 0.78 | APEX1 (0.46) | MAPTPOLBHPGDALDH1A1CYP3A4 | |
| SCHEMBL8978656 | 0.78 | KMT2A (0.38) | MAPTALDH1A1CYP2C19CYP1A2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11976056-B2 | Substituted alkoxypyridinyl indolsulfonamides | UCB PHARMA GMBH (DE) | 2024-05-07 | — | — | US | disclosed |
| CN-112292375-B | Substituted alkoxypyridinyl indole sulfonamides | 优时比制药有限公司 | 2023-12-05 | — | — | CN | disclosed |
| EP-4086248-A1 | SUBSTITUTED ALKOXYPYRIDINYL INDOLSULFONAMIDES | UCB Pharma GmbH (DE) | 2022-11-09 | — | — | EP | disclosed |
| EP-3810587-B1 | SUBSTITUTED ALKOXYPYRIDINYL INDOLSULFONAMIDES | UCB PHARMA GMBH (DE) | 2022-08-10 | — | — | EP | disclosed |
| US-20210214337-A1 | SUBSTITUTED ALKOXYPYRIDINYL INDOLSULFONAMIDES | UCB PHARMA GMBH (DE) | 2021-07-15 | — | — | US | disclosed |
| EP-3810587-A1 | SUBSTITUTED ALKOXYPYRIDINYL INDOLSULFONAMIDES | UCB Pharma GmbH (DE) | 2021-04-28 | — | — | EP | disclosed |
| CN-112292375-A | Substituted alkoxypyridylindolesulfonamides | 优时比制药有限公司 | 2021-01-29 | — | — | CN | disclosed |
| WO-2019243398-A1 | SUBSTITUTED ALKOXYPYRIDINYL INDOLSULFONAMIDES | UCB PHARMA GMBH (DE) | 2019-12-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210214337-A1 | SUBSTITUTED ALKOXYPYRIDINYL INDOLSULFONAMIDES | GPR119, GPR17, GPR27 | MAPT 2575/4885POLB 4025/4885HPGD 1080/4885 |
| US-11976056-B2 | Substituted alkoxypyridinyl indolsulfonamides | GPR119, GPR17, GPR27 | MAPT 2575/4885POLB 4025/4885HPGD 1080/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.