Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 2/20 | 0.43 |
| ▸ | MMP9 | P14780 | 2/20 | 0.43 |
| ▸ | MMP13 | P45452 | 2/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP7 | P09237 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18173570 | 0.94 | CYP2D6 (0.46) | CYP2D6ALDH1A1KDM4EGPR119KMT2A | |
| SCHEMBL16245059 | 0.93 | CYP2D6 (0.55) | CYP2D6ALDH1A1KDM4EGPR119KMT2A | |
| SCHEMBL29426713 | 0.84 | ALDH1A1 (0.46) | CYP2D6ALDH1A1KDM4EGPR119KMT2A | |
| SCHEMBL25199281 | 0.84 | ALDH1A1 (0.46) | ALDH1A1KDM4EKMT2ACHRM2CHRM1 | |
| SCHEMBL9852971 | 0.84 | CYP2D6 (0.62) | CYP2D6ALDH1A1KDM4EKMT2ATP53 | |
| SCHEMBL20595140 | 0.83 | CYP2D6 (0.57) | CYP2D6ALDH1A1KDM4EKMT2AMAPK1 | |
| SCHEMBL30003332 | 0.83 | CYP2D6 (0.42) | CYP2D6ALDH1A1KDM4EGPR119KMT2A | |
| SCHEMBL3789109 | 0.82 | SMN1; SMN2 (0.51) | CYP2D6MMP3MMP9MMP13MMP2 | |
| SCHEMBL3615713 | 0.82 | SMN1; SMN2 (0.51) | CYP2D6MMP3MMP9MMP13MMP2 | |
| SCHEMBL8788495 | 0.82 | SMN1; SMN2 (0.51) | CYP2D6MMP3MMP9MMP13MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3810594-A1 | OGA INHIBITOR COMPOUNDS | Janssen Pharmaceutica NV (BE) | 2021-04-28 | — | — | EP | disclosed |
| WO-2019243527-A1 | OGA INHIBITOR COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2019-12-26 | — | — | WO | disclosed |