Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MMP3 | P08254 | 2/20 | 0.46 |
| ▸ | MMP9 | P14780 | 2/20 | 0.46 |
| ▸ | MMP13 | P45452 | 2/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP7 | P09237 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4448525 | 0.94 | ALDH1A1 (0.43) | ALDH1A1KDM4EMMP3MMP9MMP13 | |
| SCHEMBL4012966 | 0.94 | ALDH1A1 (0.50) | ALDH1A1KDM4EMMP3MMP9MMP13 | |
| SCHEMBL30058727 | 0.91 | KMT2A (0.44) | ALDH1A1KDM4EMMP3MMP9MMP13 | |
| SCHEMBL6408846 | 0.86 | ALDH1A1 (0.49) | ALDH1A1KDM4EMMP3MMP9MMP13 | |
| SCHEMBL23250054 | 0.85 | KMT2A (0.46) | ALDH1A1KDM4EMMP3MMP9MMP13 | |
| SCHEMBL10385453 | 0.84 | ALDH1A1 (0.58) | ALDH1A1KDM4EKMT2ANPSR1TP53 | |
| SCHEMBL21597017 | 0.84 | CYP2D6 (0.50) | ALDH1A1KDM4EMMP3MMP9MMP13 | |
| SCHEMBL30058693 | 0.84 | KMT2A (0.43) | ALDH1A1KDM4EMMP3MMP9MMP13 | |
| SCHEMBL12468497 | 0.82 | MMP13 (0.44) | ALDH1A1KDM4EMMP3MMP9MMP13 | |
| SCHEMBL15392230 | 0.82 | PDK1 (0.45) | ALDH1A1KDM4EMMP3MMP9MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4181909-A2 | BISPECIFIC ANTAGONISTS OF RETINOL-BINDING PROTEIN 4 THAT STABILIZE TRANSTHYRETIN TETRAMERS, THEIR PREPARATION, AND USE IN THE TREATMENT OF COMMON AGE-RELATED COMORBIDITIES | The Trustees Of Columbia University In The City Of New York (US) | 2023-05-24 | — | — | EP | disclosed |