Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | APLNR | P35414 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28554070 | 0.84 | SLC13A5 (0.39) | TDP1SLC13A5GAAMAPTBTK | |
| SCHEMBL21598464 | 0.76 | ATR (0.38) | TDP1SLC13A5ACACBRAB9AL3MBTL1 | |
| SCHEMBL2006064 | 0.75 | SLC13A5 (0.41) | TDP1SLC13A5GAAMAPTBTK | |
| SCHEMBL8699109 | 0.75 | TDP1 (0.41) | TDP1SLC13A5GAAMAPTALDH1A1 | |
| SCHEMBL16812908 | 0.72 | APLNR (0.43) | TDP1SLC13A5BTKALDH1A1NPC1 | |
| SCHEMBL14995272 | 0.71 | TSPO (0.41) | GAAALDH1A1SMN1; SMN2 | |
| SCHEMBL1725253 | 0.70 | ALDH1A1 (0.49) | TDP1GAAMAPTALDH1A1NPC1 | |
| SCHEMBL24683219 | 0.70 | APLNR (0.44) | GAAMAPTBTKALDH1A1NPC1 | |
| SCHEMBL6114094 | 0.70 | SLC13A5 (0.36) | TDP1SLC13A5GAAMAPTBTK | |
| SCHEMBL10855883 | 0.68 | TDP1 (0.38) | TDP1SLC13A5GAAMAPTFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3807266-A1 | PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS | Janssen Pharmaceutica N.V. (BE) | 2021-04-21 | — | — | EP | disclosed |
| WO-2019243964-A1 | PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-12-26 | — | — | WO | disclosed |